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Details on Person UniProt:P42695 NCAPD3
| Class:Id | ReferenceGeneProduct:67476 |
|---|---|
| _chainChangeLog | chain:1-1498 added on Sat February 7 2015 |
| _displayName | UniProt:P42695 NCAPD3 |
| _timestamp | 2026-02-20 22:41:59 |
| chain | chain:1-1498 |
| checksum | 038033DA393E4310 |
| comment | FUNCTION Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).SUBUNIT Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.INTERACTION The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Condensin-2 complex subunit D3 alternativeName: Non-SMC condensin II complex subunit D3 shortName: hCAP-D3 |
| geneName | NCAPD3 CAPD3 KIAA0056 |
| identifier | P42695 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Coiled coil Disease variant DNA condensation Mitosis Nucleus Phosphoprotein Primary microcephaly Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NCAPD3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958188] ENSEMBL:ENSG00000151503 NCAPD3 [Homo sapiens] |
| secondaryIdentifier | CNDD3_HUMAN A6NFS2 Q4KMQ9 |
| sequenceLength | 1498 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1629790] NCAPD3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2294587] p-T1415-NCAPD3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2294594] p-T1415,S1419-NCAPD3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8958278] NCAPD3 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2294605] O-phospho-L-threonine at 1415 [ModifiedResidue:3214379] O-phospho-L-serine at 1419 |
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No pathways have been reviewed or authored by UniProt:P42695 NCAPD3 (67476)
