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Details on Person TBK1 and IKK epsilon(IKKi) are described as essential regula...
| Class:Id | Summation:674704 |
|---|---|
| _displayName | TBK1 and IKK epsilon(IKKi) are described as essential regula... |
| _timestamp | 2011-05-23 20:20:06 |
| created | [InstanceEdit:674705] Shamovsky, V, 2010-05-05 |
| literatureReference | [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways |
| modified | [InstanceEdit:1268027] Shamovsky, V, 2011-05-09 [InstanceEdit:1273407] Shamovsky, V, 2011-05-11 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 |
| text | TBK1 and IKK epsilon(IKKi) are described as essential regulators of pathogen-triggered IFN gene activation through the direct phosphorylation of IFN regulatory factors. Embryonic fibroblast cells from TBK1-deficient mice show decreased IRF3 activation and IFN induction by poly IC, while IKKi-deficient cells show normal IRF3 activation. However, the activation of IRF3 is totally abolished in TBK1 and IKKi double-deficient cells, indicating that the functions of TBK1 and IKKi are redundant in mouse embryo fibroblast cells.[Hemmi et al 2004]. TBK1/IKKi interact with SIKE (Suppressor of IKK epsilon), which was shown to act as an inhibitor of TBK1/IKKi-mediated type I IFN production, but not NF-kB activation signaling[Huang J et al 2005]. |
| (summation) | [Pathway:434136] Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 [Gallus gallus] [Reaction:1227885] TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation [Gallus gallus] |
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