Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q15398 DLGAP5
| Class:Id | ReferenceGeneProduct:67464 |
|---|---|
| _chainChangeLog | chain:1-846 added on Sat February 7 2015 |
| _displayName | UniProt:Q15398 DLGAP5 |
| _timestamp | 2024-11-03 20:14:03 |
| chain | chain:1-846 |
| checksum | 588BAF238D6FFB72 |
| comment | FUNCTION Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.SUBUNIT Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.INTERACTION Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.ALTERNATIVE PRODUCTS Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.DEVELOPMENTAL STAGE Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.PTM Ubiquitinated, leading to its degradation.PTM Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.SIMILARITY Belongs to the SAPAP family.CAUTION It was localized to the spindle and the spindle pole (PubMed:12527899) but was later found to be localized to the spindle and to be excluded from the spindle pole (PubMed:15561729).SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Disks large-associated protein 5 shortName: DAP-5 alternativeName: Discs large homolog 7 alternativeName: Disks large-associated protein DLG7 alternativeName: Hepatoma up-regulated protein shortName: HURP |
| geneName | DLGAP5 DLG7 KIAA0008 |
| identifier | Q15398 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Coiled coil Cytoplasm Cytoskeleton Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DLGAP5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988358] ENSEMBL:ENSG00000126787 DLGAP5 [Homo sapiens] |
| secondaryIdentifier | DLGP5_HUMAN A8MTM6 B4DRM8 Q86T11 Q8NG58 |
| sequenceLength | 846 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:227191] UniProt:Q15398-2 DLGAP5 [Homo sapiens] [ReferenceIsoform:405846] UniProt:Q15398-1 DLGAP5 [Homo sapiens] [ReferenceIsoform:8967821] UniProt:Q15398-3 DLGAP5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:264452] DLGAP5 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15398 DLGAP5 (67464)
