Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P18887 XRCC1
| Class:Id | ReferenceGeneProduct:67456 |
|---|---|
| _chainChangeLog | chain:1-633 added on Fri February 6 2015 |
| _displayName | UniProt:P18887 XRCC1 |
| _timestamp | 2024-11-03 20:03:57 |
| chain | chain:1-633 |
| checksum | 76174967D034F89F |
| comment | FUNCTION Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483).SUBUNIT Homodimer (PubMed:16397295). Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3) (PubMed:19155274, PubMed:19336415). Interacts with APTX and APLF (PubMed:14755728, PubMed:15044383, PubMed:15380105, PubMed:17353262, PubMed:17507382). Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1 (PubMed:19934257). Interacts with (poly-ADP-ribosylated) PARP1 (PubMed:34811483).INTERACTION Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814).TISSUE SPECIFICITY Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).PTM Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.PTM Sumoylated.POLYMORPHISM Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: fullName evidence="27"DNA repair protein XRCC1 alternativeName: X-ray repair cross-complementing protein 1 |
| geneName | XRCC1 |
| identifier | P18887 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromosome DNA damage DNA repair Isopeptide bond Neurodegeneration Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | XRCC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8954730] ENSEMBL:ENSG00000073050 XRCC1 [Homo sapiens] |
| secondaryIdentifier | XRCC1_HUMAN Q6IBS4 Q9HCB1 |
| sequenceLength | 633 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:67455] XRCC1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P18887 XRCC1 (67456)
