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Details on Person UniProt:Q92889 ERCC4
| Class:Id | ReferenceGeneProduct:67446 |
|---|---|
| _chainChangeLog | chain:1-916 added on Sat February 7 2015 |
| _displayName | UniProt:Q92889 ERCC4 |
| _timestamp | 2024-11-03 19:44:15 |
| chain | chain:1-916 |
| checksum | C58CDE900378CCA8 |
| comment | FUNCTION Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.COFACTOR Heterodimer composed of ERCC1 and ERCC4/XPF (PubMed:10413517, PubMed:16076955, PubMed:16338413, PubMed:25538220, PubMed:32034146). Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair (PubMed:19595721, PubMed:19595722, PubMed:19596235, PubMed:19596236, PubMed:25538220).INTERACTION Localizes to sites of DNA damage.ALTERNATIVE PRODUCTS Acetylation at Lys-911 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Glu-907 and Lys-911, thereby exposing a second binding site for ERCC1 (PubMed:32034146). Deacetylated by SIRT1 (PubMed:32034146).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the XPF family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: DNA repair endonuclease XPF ecNumber evidence="4"3.1.-.- alternativeName: fullName evidence="28"DNA excision repair protein ERCC-4 alternativeName: fullName evidence="27"DNA repair protein complementing XP-F cells alternativeName: fullName evidence="27"Xeroderma pigmentosum group F-complementing protein |
| geneName | ERCC4 ERCC11 XPF |
| identifier | Q92889 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosome Cockayne syndrome Disease variant DNA damage DNA repair DNA-binding Dwarfism Endonuclease Fanconi anemia Hydrolase Isopeptide bond Magnesium Nuclease Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation Xeroderma pigmentosum |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ERCC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001543] ENSEMBL:ENSG00000175595 ERCC4 [Homo sapiens] |
| secondaryIdentifier | XPF_HUMAN A5PKV6 A8K111 O00140 Q8TD83 |
| sequenceLength | 916 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976832] UniProt:Q92889-1 ERCC4 [Homo sapiens] [ReferenceIsoform:8976833] UniProt:Q92889-2 ERCC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:67445] ERCC4 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92889 ERCC4 (67446)
