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Details on Person UniProt:P23025 XPA
| Class:Id | ReferenceGeneProduct:67438 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-273 added on Fri February 6 2015;initiator methionine:1 for 67438 removed on Fri Nov 03 2023;initiator methionine: for 67438 added on Fri Nov 03 2023;initiator methionine: for 67438 removed on Fri Aug 15 2025;initiator methionine:1 for 67438 added on Fri Aug 15 2025 |
| _displayName | UniProt:P23025 XPA |
| _timestamp | 2025-08-15 21:20:06 |
| chain | initiator methionine:1 chain:2-273 |
| checksum | F89F735219A8494B |
| comment | FUNCTION Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769).SUBUNIT Interacts with GPN1. Interacts with RPA1 and RPA2; the interaction is direct and associates XPA with the RPA complex. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. During NER binds XPD/ERCC2 and XPB/ERCC3 of transcription factor IIH (TFIIH), bridging the 2 proteins (PubMed:31253769).INTERACTION Expressed in various cell lines and in skin fibroblasts.PTM ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.PTM Ubiquitinated by HERC2 leading to degradation by the proteasome.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the XPA family.ONLINE INFORMATION Nature's flaws - Issue 142 of September 2012 |
| description | recommendedName: DNA repair protein complementing XP-A cells alternativeName: Xeroderma pigmentosum group A-complementing protein |
| geneName | XPA XPAC |
| identifier | P23025 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Disease variant DNA damage DNA repair DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Xeroderma pigmentosum Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | XPA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998684] ENSEMBL:ENSG00000136936 XPA [Homo sapiens] |
| secondaryIdentifier | XPA_HUMAN Q5T1U9 Q6LCW7 Q6LD02 |
| sequenceLength | 273 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P23025 XPA (67438)
