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Details on Person UniProt:Q9Y6F9 WNT6
| Class:Id | ReferenceGeneProduct:67384 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-365 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y6F9 WNT6 |
| _timestamp | 2024-11-03 20:22:15 |
| chain | signal peptide:1-24 chain:25-365 |
| checksum | 928DE396C58E295B |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.SUBUNIT Interacts with PORCN.SUBCELLULAR LOCATION Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-6 |
| geneName | WNT6 |
| identifier | Q9Y6F9 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WNT6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992251] ENSEMBL:ENSG00000115596 WNT6 [Homo sapiens] |
| secondaryIdentifier | WNT6_HUMAN Q9H1J6 Q9H238 |
| sequenceLength | 365 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:517408] WNT6 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3238245] N4GlycoAsn-WNT6 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238308] WNT6 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238352] N4GlycoAsn-PalmS WNT6 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247781] N4GlycoAsn-PalmS WNT6 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247815] N4GlycoAsn-PalmS WNT6 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3247817] N4GlycoAsn-PalmS WNT6 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3781958] N4GlycoAsn-PalmS WNT6 [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3781984] N4GlycoAsn-PalmS WNT6 [extracellular exosome] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3238138] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:3238197] O-palmitoleyl-L-serine at 228 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y6F9 WNT6 (67384)
