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Details on Person UniProt:Q93097 WNT2B
| Class:Id | ReferenceGeneProduct:67360 |
|---|---|
| _chainChangeLog | signal peptide:1- added on Fri February 6 2015;chain:-391 added on Fri February 6 2015 |
| _displayName | UniProt:Q93097 WNT2B |
| _timestamp | 2026-02-20 22:40:05 |
| chain | signal peptide:1- chain:-391 |
| checksum | BD7BB7F795FB33B1 |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD4 and FZD5 (By similarity).INTERACTION Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-2b alternativeName: fullName evidence="13"Protein Wnt-13 |
| geneName | WNT2B WNT13 |
| identifier | Q93097 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Disease variant Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | WNT2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000418] ENSEMBL:ENSG00000134245 WNT2B [Homo sapiens] |
| secondaryIdentifier | WNT2B_HUMAN O14903 Q5TEH9 Q5TEI2 Q9HDC1 Q9HDC2 |
| sequenceLength | 391 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155794] UniProt:Q93097-2 WNT2B [Homo sapiens] [ReferenceIsoform:412540] UniProt:Q93097-1 WNT2B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:517467] WNT2B(?-391) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3238269] N4GlycoAsn-WNT2B(1-391) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238286] WNT2B(1-391) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238367] N4GlycoAsn-PalmS WNT2B(1-391) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247776] N4GlycoAsn-PalmS WNT2B(1-391) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247782] N4GlycoAsn-PalmS WNT2B(1-391) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3247812] N4GlycoAsn-PalmS WNT2B(1-391) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3781959] N4GlycoAsn-PalmS WNT2B(1-391) [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:3781976] N4GlycoAsn-PalmS WNT2B(1-391) [endocytic vesicle membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3238125] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:3238200] O-palmitoleyl-L-serine at 243 |
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No pathways have been reviewed or authored by UniProt:Q93097 WNT2B (67360)
