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Details on Person UniProt:O00744 WNT10B
| Class:Id | ReferenceGeneProduct:67358 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-389 added on Fri February 6 2015 |
| _displayName | UniProt:O00744 WNT10B |
| _timestamp | 2024-11-03 20:08:28 |
| chain | signal peptide:1-28 chain:29-389 |
| checksum | F973F2CA0DB115EF |
| comment | FUNCTION Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).INTERACTION Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.DEVELOPMENTAL STAGE Infant brain has higher levels of WNT10B than adult brain.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. Potential genotype-phenotype correlation between variants and the positions of missing teeth.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-10b alternativeName: Protein Wnt-12 |
| geneName | WNT10B WNT12 |
| identifier | O00744 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Disease variant Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Phosphoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WNT10B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997527] ENSEMBL:ENSG00000169884 WNT10B [Homo sapiens] |
| secondaryIdentifier | WN10B_HUMAN B2R7A5 O00747 Q4VAJ4 Q4VAJ5 Q8WZ97 |
| sequenceLength | 389 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971742] UniProt:O00744-1 WNT10B [Homo sapiens] [ReferenceIsoform:8971743] UniProt:O00744-2 WNT10B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:517471] WNT10B [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3238220] N4GlycoAsn-WNT10B [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238279] WNT10B [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238333] N4GlycoAsn-PalmS WNT10B [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247775] N4GlycoAsn-PalmS WNT10B [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3247791] N4GlycoAsn-PalmS WNT10B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3247821] N4GlycoAsn-PalmS WNT10B [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:3781957] N4GlycoAsn-PalmS WNT10B [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:3781985] N4GlycoAsn-PalmS WNT10B [endocytic vesicle membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3238129] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:3238204] O-palmitoleyl-L-serine at 253 |
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No pathways have been reviewed or authored by UniProt:O00744 WNT10B (67358)
