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Details on Person UniProt:Q9GZT5 WNT10A
| Class:Id | ReferenceGeneProduct:67356 |
|---|---|
| _chainChangeLog | signal peptide:1-35 added on Fri February 6 2015;chain:36-417 added on Fri February 6 2015 |
| _displayName | UniProt:Q9GZT5 WNT10A |
| _timestamp | 2024-11-03 19:44:15 |
| chain | signal peptide:1-35 chain:36-417 |
| checksum | 868DF5146A895319 |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:28589954, PubMed:29178643). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).SUBCELLULAR LOCATION Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-10a |
| geneName | WNT10A |
| identifier | Q9GZT5 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein Disease variant Disulfide bond Ectodermal dysplasia Extracellular matrix Glycoprotein Hypotrichosis Lipoprotein Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WNT10A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998682] ENSEMBL:ENSG00000135925 WNT10A [Homo sapiens] |
| secondaryIdentifier | WN10A_HUMAN Q53S44 Q96TA7 Q9H7S8 |
| sequenceLength | 417 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:517407] WNT10A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3238217] N4GlycoAsn-WNT10A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238276] WNT10A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238331] N4GlycoAsn-PalmS WNT10A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247783] N4GlycoAsn-PalmS WNT10A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3247785] N4GlycoAsn-PalmS WNT10A [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247787] N4GlycoAsn-PalmS WNT10A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3781950] N4GlycoAsn-PalmS WNT10A [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3781969] N4GlycoAsn-PalmS WNT10A [extracellular exosome] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3238132] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:3238205] O-palmitoleyl-L-serine at 268 |
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No pathways have been reviewed or authored by UniProt:Q9GZT5 WNT10A (67356)
