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Details on Person UniProt:O14905 WNT9B
Class:Id
ReferenceGeneProduct:67352
_chainChangeLog
signal peptide:1-22 added on Fri February 6 2015;chain:23-357 added on Fri February 6 2015
_displayName
UniProt:O14905 WNT9B
_timestamp
2024-11-03 20:12:48
chain
signal peptide:1-22 chain:23-357
checksum
CC22162F9D294CB8
comment
FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 (PubMed:20093360). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).SUBCELLULAR LOCATION Moderately expressed in fetal kidney and adult kidney. Also found in brain.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.SIMILARITY Belongs to the Wnt family.
description
recommendedName: Protein Wnt-9b alternativeName: Protein Wnt-14b alternativeName: Protein Wnt-15
geneName
WNT9B WNT14B WNT15 UNQ6973/PRO21956
identifier
O14905
isSequenceChanged
FALSE
keyword
Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway
