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Details on Person UniProt:O14904 WNT9A
| Class:Id | ReferenceGeneProduct:67350 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Fri February 6 2015;chain:30-365 added on Fri February 6 2015 |
| _displayName | UniProt:O14904 WNT9A |
| _timestamp | 2024-11-03 20:12:48 |
| chain | signal peptide:1-29 chain:30-365 |
| checksum | 1E1284D744C6A9B2 |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).INTERACTION Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-9a alternativeName: Protein Wnt-14 |
| geneName | WNT9A WNT14 |
| identifier | O14904 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WNT9A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002749] ENSEMBL:ENSG00000143816 WNT9A [Homo sapiens] |
| secondaryIdentifier | WNT9A_HUMAN A6NLW2 Q2M2J3 Q5VWU0 Q96S50 |
| sequenceLength | 365 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:517386] WNT9A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3238261] N4GlycoAsn-WNT9A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238324] WNT9A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3238364] N4GlycoAsn-PalmS WNT9A [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:3247800] N4GlycoAsn-PalmS WNT9A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3247805] N4GlycoAsn-PalmS WNT9A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3247822] N4GlycoAsn-PalmS WNT9A [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:3781940] N4GlycoAsn-PalmS WNT9A [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3781946] N4GlycoAsn-PalmS WNT9A [extracellular exosome] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3238122] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:3238189] O-palmitoleyl-L-serine at 221 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14904 WNT9A (67350)
