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Details on Person UniProt:P42768 WAS
| Class:Id | ReferenceGeneProduct:67298 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-502 added on Fri February 6 2015;initiator methionine:1 for 67298 removed on Fri Nov 03 2023;initiator methionine: for 67298 added on Fri Nov 03 2023;initiator methionine: for 67298 removed on Fri Aug 15 2025;initiator methionine:1 for 67298 added on Fri Aug 15 2025 |
| _displayName | UniProt:P42768 WAS |
| _timestamp | 2025-08-15 21:35:22 |
| chain | initiator methionine:1 chain:2-502 |
| checksum | 7228428672B7CB78 |
| comment | FUNCTION Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).SUBUNIT Binds the Arp2/3 complex (PubMed:12769847). Interacts with CDC42, RAC, NCK, HCK, FYN, SRC kinase FGR, BTK, ABL1, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma (PubMed:10360578, PubMed:12235133, PubMed:15235593, PubMed:8643625, PubMed:9405671). Interacts (via C-terminus) with ALDOA (PubMed:17329259). Interacts with NCK1 (via SH3 domains) (By similarity). Interacts with FCHSD2 (By similarity).SUBUNIT (Microbial infection) Interacts with E.coli effector protein EspF(U).INTERACTION Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.DOMAIN The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand.DOMAIN The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation.PTM Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION WAS mutation dbONLINE INFORMATION Wiskott-Aldrich syndrome protein entry |
| description | recommendedName: fullName evidence="38"Actin nucleation-promoting factor WAS alternativeName: Wiskott-Aldrich syndrome protein shortName: WASp |
| geneName | WAS IMD2 |
| identifier | P42768 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | WAS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999850] ENSEMBL:ENSG00000015285 WAS [Homo sapiens] |
| secondaryIdentifier | WASP_HUMAN Q9BU11 Q9UNJ9 |
| sequenceLength | 502 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201879] WAS [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2197668] p-Y291-WAS [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2197673] O4'-phospho-L-tyrosine at 291 |
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No pathways have been reviewed or authored by UniProt:P42768 WAS (67298)
