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Details on Person UniProt:O43516 WIPF1
| Class:Id | ReferenceGeneProduct:67280 |
|---|---|
| _chainChangeLog | chain:1-503 added on Fri February 6 2015 |
| _displayName | UniProt:O43516 WIPF1 |
| _timestamp | 2024-11-03 19:59:24 |
| chain | chain:1-503 |
| checksum | 09B7A95E6808A46D |
| comment | FUNCTION Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.SUBUNIT Binds to WAS, profilin and actin. Binds to WASL (By similarity). Interacts with DBNL. Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).INTERACTION Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).ALTERNATIVE PRODUCTS Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.DOMAIN Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL.SIMILARITY Belongs to the verprolin family. |
| description | recommendedName: WAS/WASL-interacting protein family member 1 alternativeName: Protein PRPL-2 alternativeName: Wiskott-Aldrich syndrome protein-interacting protein shortName: WASP-interacting protein |
| geneName | WIPF1 WASPIP WIP |
| identifier | O43516 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Actin-binding Alternative splicing Cell projection Cytoplasm Cytoplasmic vesicle Cytoskeleton Methylation Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WIPF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8954658] ENSEMBL:ENSG00000115935 WIPF1 [Homo sapiens] |
| secondaryIdentifier | WIPF1_HUMAN B8ZZM1 D3DPE4 Q15220 Q53TA9 Q6MZU9 Q9BU37 Q9UNP1 |
| sequenceLength | 503 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:254764] UniProt:O43516-2 WIPF1 [Homo sapiens] [ReferenceIsoform:254765] UniProt:O43516-3 WIPF1 [Homo sapiens] [ReferenceIsoform:254766] UniProt:O43516-4 WIPF1 [Homo sapiens] [ReferenceIsoform:401533] UniProt:O43516-1 WIPF1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201874] WIPF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:203016] WIPF1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43516 WIPF1 (67280)
