Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P04275 VWF
| Class:Id | ReferenceGeneProduct:67272 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-763 added on Fri February 6 2015;chain:764-2813 added on Fri February 6 2015 |
| _displayName | UniProt:P04275 VWF |
| _timestamp | 2024-11-03 19:39:36 |
| chain | signal peptide:1-22 chain:23-763 chain:764-2813 |
| checksum | D5C1C78360917C29 |
| comment | FUNCTION Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.SUBUNIT Multimeric. Interacts with F8.INTERACTION Localized to storage granules.ALTERNATIVE PRODUCTS Plasma.DOMAIN The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.PTM All cysteine residues are involved in intrachain or interchain disulfide bonds.PTM N- and O-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.ONLINE INFORMATION von Willebrand factor (vWF) mutation dbONLINE INFORMATION Von Willebrand factor entry |
| description | recommendedName: von Willebrand factor shortName: vWF component recommendedName: von Willebrand antigen 2 alternativeName: von Willebrand antigen II /component |
| geneName | VWF F8VWF |
| identifier | P04275 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Blood coagulation Cell adhesion Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Hemostasis Proteomics identification Reference proteome Repeat Secreted Signal von Willebrand disease |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | VWF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957777] ENSEMBL:ENSG00000110799 VWF [Homo sapiens] |
| secondaryIdentifier | VWF_HUMAN Q8TCE8 Q99806 |
| sequenceLength | 2813 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968617] UniProt:P04275-1 VWF [Homo sapiens] [ReferenceIsoform:8968618] UniProt:P04275-2 VWF [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:67271] VWF(23-763) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:114662] VWF(23-763) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:139945] VWF(23-763) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158327] VWF(764-2813) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8958383] VWF [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9822534] VWF (1606-2813) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9822545] VWF(764-1605) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9823588] VWF S1783A (764-2813) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9823611] VWF W1745C (764-2813) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9823615] VWF S1731T (764-2813) [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:9823583] L-serine 1783 replaced with L-alanine [ReplacedResidue:9823592] L-serine 1731 replaced with L-threonine [ReplacedResidue:9823602] L-tryptophan 1745 replaced with L-cysteine [ReplacedResidue:9823635] L-histidine 1786 replaced with L-aspartic acid [ReplacedResidue:9823659] L-lysine 1794 replaced with L-glutamic acid [ReplacedResidue:9823682] L-serine 1731 replaced with L-leucine [ReplacedResidue:9823700] L-serine 1387 replaced with L-isoleucine [ReplacedResidue:9823702] L-serine 1358 replaced with L-asparagine [ReplacedResidue:9823704] L-serine 1394 replaced with L-phenylalanine [ReplacedResidue:9823708] L-glutamine 1402 replaced with L-proline |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P04275 VWF (67272)
