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Details on Person UniProt:O14975 SLC27A2

Class:Id	ReferenceGeneProduct:67210
_chainChangeLog	chain:1-620 added on Fri February 6 2015
_displayName	UniProt:O14975 SLC27A2
_timestamp	2025-02-21 19:42:49
chain	chain:1-620
checksum	752E2FFBB2E47C26
comment	FUNCTION Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735).FUNCTION Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:10198260, PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).FUNCTION Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.CATALYTIC ACTIVITY a fatty acid(in) = a fatty acid(out)CATALYTIC ACTIVITY (9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)CATALYTIC ACTIVITY a fatty acid(in) = a fatty acid(out)CATALYTIC ACTIVITY a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 3,7,11,15-tetramethylhexadecanoate + ATP + CoA = phytanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 2,6,10,14-tetramethylpentadecanoate + ATP + CoA = pristanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphateBIOPHYSICOCHEMICAL PROPERTIES Expressed in liver, kidney, placenta, intestine, brain, heart, and colon (PubMed:10198260, PubMed:21768100, PubMed:24269233). Predominantly expressed in liver (PubMed:20530735).TISSUE SPECIFICITY Expressed in liver, placenta, and intestine, but much lower relative to isoform 1.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family.
description	recommendedName: fullName evidence="20"Long-chain fatty acid transport protein 2 alternativeName: Arachidonate--CoA ligase ecNumber evidence="1"6.2.1.15 alternativeName: fullName evidence="18"Fatty acid transport protein 2 shortName evidence="18"FATP-2 alternativeName: Fatty-acid-coenzyme A ligase, very long-chain 1 alternativeName: Long-chain-fatty-acid--CoA ligase ecNumber evidence="3 5 6"6.2.1.3 alternativeName: Phytanate--CoA ligase ecNumber evidence="3"6.2.1.24 alternativeName: Solute carrier family 27 member 2 alternativeName: THCA-CoA ligase ecNumber evidence="6"6.2.1.7 alternativeName: fullName evidence="14 15 16"Very long-chain acyl-CoA synthetase shortName evidence="18"VLACS shortName evidence="14 15 16"VLCS ecNumber evidence="3 5 6 9"6.2.1.- alternativeName: Very long-chain-fatty-acid-CoA ligase
geneName	SLC27A2 ACSVL1 FACVL1 FATP2 VLACS
identifier	O14975
isSequenceChanged	FALSE
keyword	Acetylation Alternative splicing ATP-binding Cell membrane Endoplasmic reticulum Fatty acid metabolism Ligase Lipid metabolism Lipid transport Membrane Microsome Nucleotide-binding Peroxisome Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	SLC27A2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8996858] ENSEMBL:ENSG00000140284 SLC27A2 [Homo sapiens]
secondaryIdentifier	S27A2_HUMAN A8K2J7 Q53FY6 Q6PF09
sequenceLength	620
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8972554] UniProt:O14975-1 SLC27A2 [Homo sapiens] [ReferenceIsoform:8972555] UniProt:O14975-2 SLC27A2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:193386] SLC27A2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:389579] SLC27A2 [peroxisomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799565] SLC27A2 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806316] SLC27A2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9033090] SLC27A2 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O14975 SLC27A2 (67210)