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Details on Person UniProt:P01282 VIP
| Class:Id | ReferenceGeneProduct:67194 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 6 2015;propeptide:21-79 added on Fri February 6 2015;peptide:81-122 added on Fri February 6 2015;peptide:81-107 added on Fri February 6 2015;peptide:125-152 added on Fri February 6 2015;propeptide:156-170 added on Fri February 6 2015 |
| _displayName | UniProt:P01282 VIP |
| _timestamp | 2026-02-20 21:35:58 |
| chain | signal peptide:1-20 propeptide:21-79 peptide:81-122 peptide:81-107 peptide:125-152 propeptide:156-170 |
| checksum | 93EC0177F89508FD |
| comment | FUNCTION VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843).FUNCTION Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843).FUNCTION Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650).INTERACTION Belongs to the glucagon family.ONLINE INFORMATION Vasoactive intestinal peptide entry |
| description | recommendedName: VIP peptides component recommendedName: Intestinal peptide PHV-42 alternativeName: Peptide histidine valine 42 shortName: PHV-42 /component component recommendedName: Intestinal peptide PHM-27 alternativeName: Peptide histidine methioninamide 27 shortName evidence="12"PHM-27 /component component recommendedName: fullName evidence="10"Vasoactive intestinal peptide shortName evidence="10"VIP alternativeName: Vasoactive intestinal polypeptide /component |
| geneName | VIP |
| identifier | P01282 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | VIP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995781] ENSEMBL:ENSG00000146469 VIP [Homo sapiens] |
| secondaryIdentifier | VIP_HUMAN Q5TCY8 Q5TCY9 Q96QK3 |
| sequenceLength | 170 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:254203] UniProt:P01282-2 VIP [Homo sapiens] [ReferenceIsoform:402254] UniProt:P01282-1 VIP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:420208] VIP(125-152) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01282 VIP (67194)
