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Details on Person UniProt:O43915 VEGFD
| Class:Id | ReferenceGeneProduct:67162 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;propeptide:22-88 added on Fri February 6 2015;chain:89-205 added on Fri February 6 2015;propeptide:206-354 added on Fri February 6 2015 |
| _displayName | UniProt:O43915 VEGFD |
| _timestamp | 2024-11-03 19:49:27 |
| chain | signal peptide:1-21 propeptide:22-88 chain:89-205 propeptide:206-354 |
| checksum | 2048D769D735173E |
| comment | FUNCTION Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.SUBUNIT Homodimer; non-covalent and antiparallel.INTERACTION Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.PTM Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.SIMILARITY Belongs to the PDGF/VEGF growth factor family. |
| description | recommendedName: fullName evidence="5"Vascular endothelial growth factor D shortName: VEGF-D alternativeName: c-Fos-induced growth factor shortName: FIGF |
| geneName | VEGFD FIGF |
| identifier | O43915 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Angiogenesis Cleavage on pair of basic residues Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Growth factor Mitogen Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | VEGFD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998089] ENSEMBL:ENSG00000165197 VEGFD [Homo sapiens] |
| secondaryIdentifier | VEGFD_HUMAN B2R7Z3 |
| sequenceLength | 354 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:67161] FIGF [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:139888] FIGF [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43915 VEGFD (67162)
