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Details on Person UniProt:P49767 VEGFC
| Class:Id | ReferenceGeneProduct:67160 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Fri February 6 2015;propeptide:32-111 added on Fri February 6 2015;chain:112-227 added on Fri February 6 2015;propeptide:228-419 added on Fri February 6 2015 |
| _displayName | UniProt:P49767 VEGFC |
| _timestamp | 2024-11-03 19:49:27 |
| chain | signal peptide:1-31 propeptide:32-111 chain:112-227 propeptide:228-419 |
| checksum | 9F598719DB3E014F |
| comment | FUNCTION Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.SUBUNIT Homodimer; non-covalent and antiparallel (PubMed:20145116). Interacts with FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3 homodimarization and activation (PubMed:23878260).INTERACTION Expressed in the spleen (PubMed:8700872, PubMed:9247316). Expressed in the lymph node, thymus, appendix and bone marrow (PubMed:9247316). Expressed in the heart, placenta, skeletal muscle, ovary and small intestine (PubMed:8617204, PubMed:8700872). Expressed in the prostate, testis and colon (PubMed:8700872).DEVELOPMENTAL STAGE Expressed in fetal lung and kidney (PubMed:8700872). Expressed in fetal liver (PubMed:28179430, PubMed:9247316).PTM Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PDGF/VEGF growth factor family. |
| description | recommendedName: Vascular endothelial growth factor C shortName: VEGF-C alternativeName: Flt4 ligand shortName: Flt4-L alternativeName: Vascular endothelial growth factor-related protein shortName: VRP |
| geneName | VEGFC |
| identifier | P49767 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Angiogenesis Cleavage on pair of basic residues Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Growth factor Mitogen Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | VEGFC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988204] ENSEMBL:ENSG00000150630 VEGFC [Homo sapiens] |
| secondaryIdentifier | VEGFC_HUMAN B2R9Q8 |
| sequenceLength | 419 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:67159] VEGFC [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:139887] VEGFC [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P49767 VEGFC (67160)
