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Details on Person UniProt:P15692-1 VEGFA
| Class:Id | ReferenceIsoform:67156 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-232 added on Fri February 6 2015;signal peptide:1-26 for 67156 removed on Fri August 11 2023;chain:27-232 for 67156 removed on Fri August 11 2023;chain:1-395 for 67156 added on Fri August 11 2023;chain:1- for 67156 added on Fri August 11 2023;chain:-395 for 67156 added on Fri August 11 2023 |
| _displayName | UniProt:P15692-1 VEGFA |
| _timestamp | 2024-11-03 19:49:26 |
| chain | chain:1-395 chain:1- chain:-395 |
| checksum | 8ADF6524B1835A2D |
| comment | FUNCTION Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity).FUNCTION Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth (PubMed:34530889). Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).FUNCTION Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.SUBUNIT Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042). Interacts with isoform 2 of BSG (PubMed:25825981). Interacts with CD82; this interaction inhibits VEGFA-mediated signaling pathway (PubMed:34530889).INTERACTION Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions.SUBCELLULAR LOCATION Cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.ALTERNATIVE PRODUCTS A subset of isoforms are produced by use of an alternative upstream CUG codon, giving rise to long isoforms which have an N-terminal extension compared to the classical shorter AUG-initiated forms. These longer forms are post-translationally processed to produce an N-terminal N-VEGF chain and a C-terminal VEGFA chain.TISSUE SPECIFICITY Higher expression in pituitary tumors than the pituitary gland.TISSUE SPECIFICITY Widely expressed.TISSUE SPECIFICITY Widely expressed.TISSUE SPECIFICITY Widely expressed.TISSUE SPECIFICITY Not widely expressed.TISSUE SPECIFICITY Not widely expressed.INDUCTION By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.PTM Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.MISCELLANEOUS Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.MISCELLANEOUS Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.MISCELLANEOUS Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.MISCELLANEOUS Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.MISCELLANEOUS Starts at an alternative upstream CUG codon.MISCELLANEOUS Starts at an alternative upstream CUG codon.MISCELLANEOUS Starts at an alternative upstream CUG codon.MISCELLANEOUS Starts at an alternative upstream CUG codon.SIMILARITY Belongs to the PDGF/VEGF growth factor family.SEQUENCE CAUTION Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.ONLINE INFORMATION VEGF entry |
| description | recommendedName: Vascular endothelial growth factor A, long form shortName evidence="27 28"L-VEGF alternativeName: Vascular permeability factor shortName: VPF component recommendedName: fullName evidence="28"N-VEGF /component component recommendedName: fullName evidence="28"VEGFA /component |
| geneName | VEGFA VEGF |
| identifier | P15692 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Alternative promoter usage Alternative splicing Angiogenesis Cytoplasm Developmental protein Differentiation Direct protein sequencing Disulfide bond Endoplasmic reticulum Extracellular matrix Glycoprotein Golgi apparatus Growth factor Heparin-binding Mitogen Nucleus Proteomics identification Reference proteome Secreted |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | VEGFA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5652229] ENSEMBL:ENSG00000112715 VEGFA [Homo sapiens] |
| secondaryIdentifier | VEGFA_HUMAN B5BU86 H0Y2S8 H0Y407 H0Y414 H0Y462 H0Y8N2 H3BLW7 O60720 O75875 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5 Q9H1W8 Q9H1W9 Q9UH58 Q9UL23 |
| sequenceLength | 395 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P15692-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:67155] VEGFA-1 [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P15692-1 VEGFA (67156)
