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Details on Person UniProt:P19320 VCAM1
| Class:Id | ReferenceGeneProduct:67138 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-739 added on Fri February 6 2015;chain:25- for 67138 added on Fri May 5 2023 |
| _displayName | UniProt:P19320 VCAM1 |
| _timestamp | 2026-02-20 22:17:46 |
| chain | signal peptide:1-24 chain:25-739 chain:25- |
| checksum | 050E2EBD39AC2FF4 |
| comment | FUNCTION Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.INDUCTION By pro-inflammatory cytokines, including TNFalpha, and also by ROS, oxidized low density lipoprotein, high glucose concentration, toll-like receptor agonists, and shear stress.DOMAIN Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM Cleaved by the metalloproteinase ADAM17 to generate the soluble form.PTM Sialoglycoprotein.PTM Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation.MISCELLANEOUS Major isoform.ONLINE INFORMATION VCAM1 entryONLINE INFORMATION VCAM-1 |
| description | recommendedName: Vascular cell adhesion protein 1 shortName: V-CAM 1 shortName: VCAM-1 alternativeName: INCAM-100 cdAntigenNameCD106/cdAntigenName component recommendedName: Soluble Vascular Cell Adhesion Molecule-1 /component |
| geneName | VCAM1 |
| identifier | P19320 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell adhesion Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | VCAM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6789335] ENSEMBL:ENSG00000162692 VCAM1 [Homo sapiens] |
| secondaryIdentifier | VCAM1_HUMAN A8K6R7 B4DKS4 E9PDD1 Q6NUP8 |
| sequenceLength | 739 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155636] UniProt:P19320-2 VCAM1 [Homo sapiens] [ReferenceIsoform:403181] UniProt:P19320-1 VCAM1 [Homo sapiens] [ReferenceIsoform:8973127] UniProt:P19320-3 VCAM1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197834] VCAM1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9940564] VCAM1 (follicular dendritic cell) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P19320 VCAM1 (67138)
