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Details on Person UniProt:O95292 VAPB
| Class:Id | ReferenceGeneProduct:67106 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-243 added on Fri February 6 2015;initiator methionine:1 for 67106 removed on Fri Nov 03 2023;initiator methionine: for 67106 added on Fri Nov 03 2023;initiator methionine: for 67106 removed on Fri Aug 15 2025;initiator methionine:1 for 67106 added on Fri Aug 15 2025 |
| _displayName | UniProt:O95292 VAPB |
| _timestamp | 2025-08-15 21:50:16 |
| chain | initiator methionine:1 chain:2-243 |
| checksum | 22AEEF9EC7FC0B3F |
| comment | FUNCTION Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369).SUBUNIT Homodimer, and heterodimer with VAPA (PubMed:20940299). Interacts with VAMP1 and VAMP2 (PubMed:20940299, PubMed:9920726). Interacts (via MSP domain) with ZFYVE27 (PubMed:19289470, PubMed:21976701). Interacts with RMDN3 (PubMed:22131369). Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (via MSP domain) with STARD3 (via phospho-FFAT motif) (PubMed:24105263, PubMed:33124732). Interacts with STARD3NL (via FFAT motif) (PubMed:24105263). Interacts with CERT1 (PubMed:16895911). Interacts with PLEKHA3 and SACM1L to form a ternary complex (PubMed:30659099). Interacts with VPS13A (via FFAT motif) (PubMed:30741634). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), OSBPL1A (via FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif) (PubMed:33124732). Interacts (via MSP domain) with WDR44 (via FFAT motif); the interactions connect the endoplasmic reticulum (ER) with the endosomal tubule (PubMed:32344433).SUBUNIT (Microbial infection) Interacts (via MSP domain) with hepatitis C virus (HCV) non-structural protein 5A (via disordered domain D3) (PubMed:16227268, PubMed:22720086). Interacts with HCV RNA-directed RNA polymerase (PubMed:16227268).INTERACTION Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.ALTERNATIVE PRODUCTS Ubiquitous. Isoform 1 predominates.DOMAIN The MSP domain binds the FFAT motif of many proteins.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.ONLINE INFORMATION ALS genetic mutations dbONLINE INFORMATION Leiden Open Variation Database (LOVD) |
| description | recommendedName: fullName evidence="22"Vesicle-associated membrane protein-associated protein B/C shortName: VAMP-B/VAMP-C shortName: VAMP-associated protein B/C shortName: VAP-B/VAP-C |
| geneName | VAPB UNQ484/PRO983 |
| identifier | O95292 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Amyotrophic lateral sclerosis Coiled coil Direct protein sequencing Disease variant Endoplasmic reticulum Host-virus interaction Isopeptide bond Membrane Neurodegeneration Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VAPB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994595] ENSEMBL:ENSG00000124164 VAPB [Homo sapiens] |
| secondaryIdentifier | VAPB_HUMAN A2A2F2 O95293 Q9P0H0 |
| sequenceLength | 243 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155626] UniProt:O95292-2 VAPB [Homo sapiens] [ReferenceIsoform:402127] UniProt:O95292-1 VAPB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:429718] VAPB [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:9715115] VAPB [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95292 VAPB (67106)
