Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9P0L0 VAPA

Class:Id	ReferenceGeneProduct:67104
_chainChangeLog	chain:1-249 added on Sat February 7 2015;chain:1-249 removed on Wed November 4 2015;initiator methionine:1 added on Wed November 4 2015;chain:2-249 added on Wed November 4 2015;initiator methionine:1 for 67104 removed on Fri Nov 03 2023;initiator methionine: for 67104 added on Fri Nov 03 2023;initiator methionine: for 67104 removed on Fri Aug 15 2025;initiator methionine:1 for 67104 added on Fri Aug 15 2025
_displayName	UniProt:Q9P0L0 VAPA
_timestamp	2025-08-15 21:12:15
chain	initiator methionine:1 chain:2-249
checksum	68B603F3A9FA5475
comment	FUNCTION Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).SUBUNIT Homodimer; disulfide-linked (PubMed:11511104, PubMed:33124732). Heterodimer with VAPB (PubMed:11511104). Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN (PubMed:10523508, PubMed:11511104, PubMed:9657962). Interacts (via MSP domain) with OSBPL1A (via FFAT motif) (PubMed:33124732). Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation (PubMed:19289470, PubMed:21976701). Interacts with OSBP (PubMed:20178991). Interacts (via C-terminus) with RSAD2/viperin (via C-terminus) (PubMed:21957124). Interacts with IFITM3 (PubMed:23601107). Interacts with OSBPL3 (phosphorylated form) (PubMed:16143324, PubMed:25447204). Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (via MSP domain) with STARD3 (via phosphorylated FFAT motif); this interaction recruits VAPA to the endosome (PubMed:24105263, PubMed:33124732). Interacts with STARD3NL (via FFAT motif) (PubMed:24105263). Interacts with CERT1 (PubMed:16895911). Interacts with PLEKHA3 and SACM1L to form a ternary complex (PubMed:30659099). Interacts with VPS13A (via FFAT motif) (PubMed:30741634). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif) (PubMed:33124732). Interacts (via MSP domain) with WDR44 (via FFAT-like motif); the interactions connect the endoplasmic reticulum (ER) with the endosomal tubule (PubMed:32344433).SUBUNIT (Microbial infection) Interacts with HCV protein NS5A and NS5B (PubMed:21957124).INTERACTION Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The MSP domain binds the FFAT motif of many proteins.SIMILARITY Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
description	recommendedName: fullName evidence="25"Vesicle-associated membrane protein-associated protein A shortName: VAMP-A shortName: VAMP-associated protein A shortName: VAP-A alternativeName: fullName evidence="24"33 kDa VAMP-associated protein shortName evidence="21 23"VAP-33
geneName	VAPA VAP33
identifier	Q9P0L0
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cell junction Cell membrane Coiled coil Disulfide bond Endoplasmic reticulum Host-virus interaction Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Tight junction Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	VAPA
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8996961] ENSEMBL:ENSG00000101558 VAPA [Homo sapiens]
secondaryIdentifier	VAPA_HUMAN A6NDZ0 D3DUI3 O75453 Q5U0E7 Q9UBZ2
sequenceLength	249
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8978115] UniProt:Q9P0L0-1 VAPA [Homo sapiens] [ReferenceIsoform:8978116] UniProt:Q9P0L0-2 VAPA [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:429677] VAPA [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799364] VAPA [azurophil granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806269] VAPA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9609920] VAPA [cytosol] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9P0L0 VAPA (67104)