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Details on Person UniProt:P63027 VAMP2
| Class:Id | ReferenceGeneProduct:67094 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-116 added on Sat February 7 2015;initiator methionine:1 for 67094 removed on Fri Nov 03 2023;initiator methionine: for 67094 added on Fri Nov 03 2023;initiator methionine: for 67094 removed on Fri Aug 15 2025;initiator methionine:1 for 67094 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63027 VAMP2 |
| _timestamp | 2025-08-15 21:35:13 |
| chain | initiator methionine:1 chain:2-116 |
| checksum | 9CD679C4F6F1B5A8 |
| comment | FUNCTION Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.SUBUNIT Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex constitutes the basic catalytic machinery of the complex neurotransmitter release apparatus (By similarity). Recruited to the SNARE complex following binding of the SNARE complex component STX1A to STXBP1 (By similarity). This complex binds to CPLX1. Interacts with POPDC1 and STX4 (By similarity). Interacts with VAPA and VAPB. Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651). Forms a complex with WDFY2 and PRKCZ (PubMed:17313651). Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP. Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (By similarity). Interacts with PICALM (PubMed:21808019, PubMed:22118466). Interacts with alpha-synuclein/SNCA (PubMed:20798282). Interacts with STX3 (By similarity).INTERACTION Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651).TISSUE SPECIFICITY Nervous system and skeletal muscle.PTM Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.PTM (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).PTM (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 59-Lys-|-Leu-60 bond and inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.PTM (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 58-Gln-|-Lys-59 bond and probably inhibits neurotransmitter release (PubMed:19543288).PTM (Microbial infection) Targeted and hydrolyzed by C.tetani tetanus toxin (tetX) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the synaptobrevin family.CAUTION A structure of a fragment of this protein in complex with the catalytic domain of C.botulinum neurotoxin type B (BoNT/B, botB) was reported; because of the lack of clear and continuous electron density for the VAMP2 peptide in the complex structure, the paper was retracted (PubMed:10932255, PubMed:19578378). However this protein is a substrate for BoNT/B (PubMed:22289120, PubMed:7803399). |
| description | recommendedName: fullName evidence="18"Vesicle-associated membrane protein 2 shortName: VAMP-2 alternativeName: Synaptobrevin-2 |
| geneName | VAMP2 SYB2 |
| identifier | P63027 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell membrane Coiled coil Cytoplasmic vesicle Disease variant Intellectual disability Membrane Phosphoprotein Proteomics identification Reference proteome Synapse Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VAMP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994594] ENSEMBL:ENSG00000220205 VAMP2 [Homo sapiens] |
| secondaryIdentifier | VAMP2_HUMAN P19065 Q9BUC2 |
| sequenceLength | 116 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:181517] VAMP2 [synaptic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:194797] VAMP2(2-59) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:194802] VAMP2(2-76) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:194815] VAMP2(2-58) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:210365] VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:210516] VAMP2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:265198] VAMP2 [secretory granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:375425] VAMP2 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:376363] VAMP2 [secretory granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:379363] VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P63027 VAMP2 (67094)
