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Details on Person UniProt:O14607 UTY
| Class:Id | ReferenceGeneProduct:67058 |
|---|---|
| _chainChangeLog | chain:1-1347 added on Fri February 6 2015 |
| _displayName | UniProt:O14607 UTY |
| _timestamp | 2025-02-21 19:34:30 |
| chain | chain:1-1347 |
| checksum | D83B8CAB861BCE60 |
| comment | FUNCTION Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.CATALYTIC ACTIVITY N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2COFACTOR Interacts with TLE1 and TLE2.SUBCELLULAR LOCATION Additional isoforms seem to exist.SIMILARITY Belongs to the UTX family. |
| description | recommendedName: Histone demethylase UTY ecNumber evidence="4"1.14.11.68 alternativeName: Ubiquitously-transcribed TPR protein on the Y chromosome alternativeName: Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein alternativeName: fullName evidence="8"[histone H3]-trimethyl-L-lysine(27) demethylase UTY |
| geneName | UTY KDM6C |
| identifier | O14607 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Dioxygenase Direct protein sequencing Iron Metal-binding Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Repeat TPR repeat Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | UTY |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988199] ENSEMBL:ENSG00000183878 UTY [Homo sapiens] |
| secondaryIdentifier | UTY_HUMAN A8K9Z3 E1U199 E1U1A0 F5H4V7 F8W8R7 O14608 |
| sequenceLength | 1347 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155616] UniProt:O14607-2 UTY [Homo sapiens] [ReferenceIsoform:401235] UniProt:O14607-1 UTY [Homo sapiens] [ReferenceIsoform:424430] UniProt:O14607-3 UTY [Homo sapiens] [ReferenceIsoform:8977676] UniProt:O14607-4 UTY [Homo sapiens] [ReferenceIsoform:8977677] UniProt:O14607-5 UTY [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8849395] KDM6C [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14607 UTY (67058)
