Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P25874 UCP1
| Class:Id | ReferenceGeneProduct:66880 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-307 added on Fri February 6 2015 |
| _displayName | UniProt:P25874 UCP1 |
| _timestamp | 2024-11-03 20:17:19 |
| chain | chain:1-307 |
| checksum | BCC99AB27171FC67 |
| comment | FUNCTION Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).CATALYTIC ACTIVITY H(+)(in) = H(+)(out)ACTIVITY REGULATION Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs (PubMed:28781081). Inhibited by purine nucleotides (PubMed:28781081). Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it (PubMed:28781081). Activated by noradrenaline and reactive oxygen species. Despite lacking canonical translational encoding for selenocysteine, a small pool of the protein has been observed to selectively incorporate selenocysteine at 'Cys-254'. Selenocysteine-modified protein is highly sensitive to redox modification and may constitute a pool of protein highly sensitive to activation by elevated levels of reactive oxygen species (ROS).SUBUNIT Most probably functions as a monomer. Binds one purine nucleotide per monomer (By similarity). However, has also been suggested to function as a homodimer or a homotetramer (PubMed:24196960). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed:24196960).INTERACTION Brown adipose tissue.PTM May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.PTM May undergo ubiquitin-mediated proteasomal degradation.SIMILARITY Belongs to the mitochondrial carrier (TC 2.A.29) family.ONLINE INFORMATION A touch of warmth - Issue 195 of September 2017 |
| description | recommendedName: fullName evidence="13"Mitochondrial brown fat uncoupling protein 1 shortName evidence="13"UCP 1 alternativeName: fullName evidence="11"Solute carrier family 25 member 7 alternativeName: fullName evidence="1"Thermogenin |
| geneName | UCP1 SLC25A7 UCP |
| identifier | P25874 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Diabetes mellitus Ion channel Ion transport Membrane Mitochondrion Mitochondrion inner membrane Obesity Oxidation Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | UCP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991071] ENSEMBL:ENSG00000109424 UCP1 [Homo sapiens] |
| secondaryIdentifier | UCP1_HUMAN Q13218 Q4KMZ3 Q68G66 |
| sequenceLength | 307 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:166394] UCP1 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P25874 UCP1 (66880)
