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Details on Person UniProt:P55089 UCN
| Class:Id | ReferenceGeneProduct:66874 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;propeptide:26-82 added on Fri February 6 2015;peptide:83-122 added on Fri February 6 2015 |
| _displayName | UniProt:P55089 UCN |
| _timestamp | 2023-11-03 15:13:30 |
| chain | signal peptide:1-25 propeptide:26-82 peptide:83-122 |
| checksum | 4F765DA75DDD4A5E |
| comment | FUNCTION Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).SUBUNIT Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).SUBCELLULAR LOCATION Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).MISCELLANEOUS Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.SIMILARITY Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
| description | recommendedName: Urocortin |
| geneName | UCN |
| identifier | P55089 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Amidation Cleavage on pair of basic residues Hearing Hormone Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | UCN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999841] ENSEMBL:ENSG00000163794 UCN [Homo sapiens] |
| secondaryIdentifier | UCN1_HUMAN Q6FG64 |
| sequenceLength | 124 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8931580] UCN(83-122) [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P55089 UCN (66874)
