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Details on Person UniProt:P62253 UBE2G1
| Class:Id | ReferenceGeneProduct:66753 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:1-170 added on Sat February 7 2015;chain:2-170 added on Sat February 7 2015;initiator methionine:1 for 66753 removed on Fri Nov 03 2023;initiator methionine: for 66753 added on Fri Nov 03 2023;initiator methionine: for 66753 removed on Fri Aug 15 2025;initiator methionine:1 for 66753 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62253 UBE2G1 |
| _timestamp | 2025-08-15 21:58:01 |
| chain | chain:1-170 initiator methionine:1 chain:2-170 |
| checksum | 36B61766D995B332 |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PATHWAY Protein modification; protein ubiquitination.INTERACTION Widely expressed, mainly in skeletal muscle.PTM Autoubiquitinated in vitro.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family. |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 G1 ecNumber evidence="5"2.3.2.23 alternativeName: E2 ubiquitin-conjugating enzyme G1 alternativeName: E217K alternativeName: UBC7 alternativeName: Ubiquitin carrier protein G1 alternativeName: Ubiquitin-protein ligase G1 component recommendedName: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed /component |
| geneName | UBE2G1 UBE2G |
| identifier | P62253 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Direct protein sequencing Nucleotide-binding Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | UBE2G1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003310] ENSEMBL:ENSG00000132388 UBE2G1 [Homo sapiens] |
| secondaryIdentifier | UB2G1_HUMAN B2R7P2 D3DTK0 Q99462 |
| sequenceLength | 170 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:947627] UBE2G1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8853510] UBE2G1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8864149] Ub-C90-UBE2G1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [InterChainCrosslinkedResidue:8853518] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 90 and 76 [ModifiedResidue:8864158] S-(glycyl)-L-cysteine (Cys-Gly) at 90 |
| (secondReferenceSequence) | [InterChainCrosslinkedResidue:8853533] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 76 and 90 |
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No pathways have been reviewed or authored by UniProt:P62253 UBE2G1 (66753)
