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Details on Person UniProt:Q16763 UBE2S
| Class:Id | ReferenceGeneProduct:66751 |
|---|---|
| _chainChangeLog | chain:1-222 added on Sat February 7 2015 |
| _displayName | UniProt:Q16763 UBE2S |
| _timestamp | 2025-02-21 19:14:06 |
| chain | chain:1-222 |
| checksum | 2842DC3DCD2AFCB5 |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2 and ANAPC4 (PubMed:27259151). Interacts with CDC20, FZR1/CDH1 and VHL (PubMed:16819549, PubMed:19822757).INTERACTION Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family. |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 S ecNumber evidence="5 6 7 12"2.3.2.23 alternativeName: E2 ubiquitin-conjugating enzyme S alternativeName: E2-EPF alternativeName: Ubiquitin carrier protein S alternativeName: Ubiquitin-conjugating enzyme E2-24 kDa alternativeName: Ubiquitin-conjugating enzyme E2-EPF5 alternativeName: Ubiquitin-protein ligase S |
| geneName | UBE2S E2EPF OK/SW-cl.73 |
| identifier | Q16763 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cell cycle Cell division Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | UBE2S |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005045] ENSEMBL:ENSG00000108106 UBE2S [Homo sapiens] |
| secondaryIdentifier | UBE2S_HUMAN Q9BTC1 |
| sequenceLength | 222 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:947622] UBE2S [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8852051] UBE2S [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8864164] Ub-C95-UBE2S [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8864181] Ub-C95-UBE2S [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8864173] S-(glycyl)-L-cysteine (Cys-Gly) at 95 |
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No pathways have been reviewed or authored by UniProt:Q16763 UBE2S (66751)
