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Details on Person UniProt:P62837 UBE2D2
| Class:Id | ReferenceGeneProduct:66707 |
|---|---|
| _chainChangeLog | chain:1-147 added on Sat February 7 2015 |
| _displayName | UniProt:P62837 UBE2D2 |
| _timestamp | 2025-05-21 21:27:51 |
| chain | chain:1-147 |
| checksum | C942BE7853CBC355 |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854, PubMed:28322253). Catalyzes 'Lys-48'-linked polyubiquitination (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:15280377). Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6 (PubMed:18359941, PubMed:28322253). Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection (PubMed:18703417, PubMed:20403326). Essential for viral activation of IRF3 (PubMed:19854139).CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11 (By similarity). Interacts with E3 ubiquitin-protein ligase PHF7; the interaction inhibits cleavage of PHF7 and promotes association of the complex with the nucleosome core particle (PubMed:37993255).INTERACTION Belongs to the ubiquitin-conjugating enzyme family. |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 D2 ecNumber evidence="10 12 13 14"2.3.2.23 alternativeName: (E3-independent) E2 ubiquitin-conjugating enzyme D2 ecNumber evidence="9"2.3.2.24 alternativeName: E2 ubiquitin-conjugating enzyme D2 alternativeName: Ubiquitin carrier protein D2 alternativeName: Ubiquitin-conjugating enzyme E2(17)KB 2 alternativeName: Ubiquitin-conjugating enzyme E2-17 kDa 2 alternativeName: Ubiquitin-protein ligase D2 alternativeName: p53-regulated ubiquitin-conjugating enzyme 1 |
| geneName | UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5B |
| identifier | P62837 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Direct protein sequencing Nucleotide-binding Proteomics identification Reference proteome Transferase Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | UBE2D2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989890] ENSEMBL:ENSG00000131508 UBE2D2 [Homo sapiens] |
| secondaryIdentifier | UB2D2_HUMAN D3DQC9 P51669 Q3MN78 Q96RP6 |
| sequenceLength | 147 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976314] UniProt:P62837-1 UBE2D2 [Homo sapiens] [ReferenceIsoform:8976315] UniProt:P62837-2 UBE2D2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:934628] UBE2D2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8864153] Ub-C85-UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8864214] Ub-C85-UBE2D2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8864213] S-(glycyl)-L-cysteine (Cys-Gly) at 85 |
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No pathways have been reviewed or authored by UniProt:P62837 UBE2D2 (66707)
