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Details on Person UniProt:P51668 UBE2D1
| Class:Id | ReferenceGeneProduct:66705 |
|---|---|
| _chainChangeLog | chain:1-147 added on Fri February 6 2015 |
| _displayName | UniProt:P51668 UBE2D1 |
| _timestamp | 2024-11-03 20:08:19 |
| chain | chain:1-147 |
| checksum | 2E96FD0179EE119D |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148).CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.INTERACTION Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.PTM Autoubiquitinated in vitro.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.CAUTION PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronic sequences on the 5'-end of this exon. A function in iron transport has been described. |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 D1 ecNumber evidence="7 11 12"2.3.2.23 alternativeName: (E3-independent) E2 ubiquitin-conjugating enzyme D1 ecNumber evidence="6"2.3.2.24 alternativeName: E2 ubiquitin-conjugating enzyme D1 alternativeName: Stimulator of Fe transport shortName: SFT alternativeName: UBC4/5 homolog alternativeName: UbcH5 alternativeName: Ubiquitin carrier protein D1 alternativeName: Ubiquitin-conjugating enzyme E2(17)KB 1 alternativeName: Ubiquitin-conjugating enzyme E2-17 kDa 1 alternativeName: Ubiquitin-protein ligase D1 |
| geneName | UBE2D1 SFT UBC5A UBCH5 UBCH5A |
| identifier | P51668 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cytoplasm Nucleotide-binding Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | UBE2D1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988188] ENSEMBL:ENSG00000072401 UBE2D1 [Homo sapiens] |
| secondaryIdentifier | UB2D1_HUMAN A6NLF6 A8K786 |
| sequenceLength | 147 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:174197] UBE2D1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:174236] UBE2D1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8864160] Ub-C85-UBE2D1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8937534] Ub-C85-UBE2D1 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8864220] S-(glycyl)-L-cysteine (Cys-Gly) at 85 |
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No pathways have been reviewed or authored by UniProt:P51668 UBE2D1 (66705)
