Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Synthesis of DNA

Class:IdPathwayDiagram:666911
_displayNameDiagram of Synthesis of DNA
_timestamp2021-11-04 22:29:30
created[InstanceEdit:666908] Gillespie, ME, 2010-05-04
height1240
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1935909] Rothfels, K, 2011-11-02
[InstanceEdit:3047094] Jupe, S, 2013-02-06
[InstanceEdit:5661318] D'Eustachio, Peter, 2015-01-10
[InstanceEdit:5693289] Matthews, Lisa, 2015-05-14
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8861990] Matthews, Lisa, 2016-02-23
[InstanceEdit:8862017] Matthews, Lisa, 2016-02-23
[InstanceEdit:8870899] Matthews, Lisa, 2016-05-12
[InstanceEdit:8939956] Jupe, Steve, 2016-09-22
[InstanceEdit:9032414] Orlic-Milacic, Marija, 2017-12-12
[InstanceEdit:9036790] Matthews, Lisa, 2018-02-08
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9658487] Matthews, Lisa, 2019-08-15
[InstanceEdit:9716774] D'Eustachio, Peter, 2021-02-24
[InstanceEdit:9757422] Orlic-Milacic, Marija, 2021-10-30
[InstanceEdit:9757788] D'Eustachio, Peter, 2021-11-04
representedPathway[Pathway:69239] Synthesis of DNA [Homo sapiens]
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<displayName>PolyUb,p-S,T-ORC1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.11678832116788321" relativeY="0.0" label="P" trackId="0" reactomeId="141612" /> <org.gk.render.RenderableFeature relativeX="0.23357664233576642" relativeY="0.0" label="P" trackId="0" reactomeId="141611" /> <org.gk.render.RenderableFeature relativeX="0.35036496350364965" relativeY="0.0" label="U" trackId="0" reactomeId="9032190" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="261" reactomeId="8848491" position="553 803" bounds="488 778 130 50" textPosition="503 778"> <Properties> <displayName>CCNA:p-T160-CDK2,CCNE:p-T160-CDK2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="263" reactomeId="174181" position="533 996" bounds="478 978 111 36" textPosition="480 978" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phospho-APC/C:Cdh1 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points="209 591, 209 623, 208 674" position="209 623" lineWidth="1.0"> <Inputs> <Input id="98" points="167 557" /> <Input id="99" points="250 556" /> </Inputs> <Outputs> <Output id="100" points="167 687" /> <Output id="101" points="260 681" /> <Output id="102" points="208 725" /> </Outputs> <Catalysts> <Catalyst id="257" points="422 613" /> </Catalysts> <Properties> <displayName>Orc1 is phosphorylated by cyclin A/CDK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="68946" points="208 783, 205 810, 157 853" position="205 810" lineWidth="1.0"> <Inputs> <Input id="102" points="208 753" /> <Input id="105" stoichiometry="3" points="137 770" /> </Inputs> <Outputs> <Output id="258" /> </Outputs> <Catalysts> <Catalyst id="259" points="124 817" /> </Catalysts> <Properties> <displayName>Phosphorylated Orc1 is ubiquitinated while still associated with chromatin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="68947" points="147 883, 163 944, 158 996" position="163 944" lineWidth="1.0"> <Inputs> <Input id="258" /> </Inputs> <Outputs> <Output id="260" /> </Outputs> <Properties> <displayName>Ubiquitinated Orc1 enters the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="68948" points="156 1027, 152 1058, 243 1064" position="152 1058" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="260" /> </Inputs> <Outputs> <Output id="125" stoichiometry="3" /> </Outputs> <Catalysts> <Catalyst id="126" points="297 1161" /> </Catalysts> <Properties> <displayName>Ubiquitinated Orc1 is degraded by the proteasome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="128" reactomeId="69005" points="454 767, 454 805, 454 837" position="454 805" lineWidth="1.0"> <Inputs> <Input id="129" points="422 756" /> <Input id="130" points="471 745" /> </Inputs> <Outputs> <Output id="240" points="427 849" /> <Output id="241" points="480 857" /> </Outputs> <Catalysts> <Catalyst id="261" points="482 804" /> </Catalysts> <Properties> <displayName>Cdc6 protein is phosphorylated by CDK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="69006" points="403 882, 409 933, 410 1002" position="409 933" lineWidth="1.0"> <Inputs> <Input id="240" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Properties> <displayName>Phosphorylated Cdc6 is exported from the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="69015" points="490 1065, 536 1065, 602 1114" position="536 1065" lineWidth="1.0"> <Inputs> <Input id="125" points="313 1065" /> <Input id="135" points="432 1034" /> <Input id="137" points="470 1080" /> </Inputs> <Outputs> <Output id="138" /> </Outputs> <Catalysts> <Catalyst id="263" points="533 1017" /> </Catalysts> <Properties> <displayName>Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="140" reactomeId="69016" points="550 1129, 367 1133, 292 1083" position="367 1133" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="138" /> </Inputs> <Outputs> <Output id="125" /> </Outputs> <Catalysts> <Catalyst id="126" points="338 1161" /> </Catalysts> <Properties> <displayName>Ubiquitinated Cdc6 is degraded by the proteasome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="69019" points="797 150, 797 191, 798 219" position="797 191" lineWidth="1.0"> <Inputs> <Input id="142" /> </Inputs> <Outputs> <Output id="143" points="762 212" /> <Output id="144" points="794 287" /> <Output id="145" points="826 238" /> <Output id="146" points="760 243" /> </Outputs> <Properties> <displayName>Mcm4,6,7 trimer forms and associates with the replication fork</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="148" reactomeId="169468" points="936 102, 928 133, 934 176" position="928 133" lineWidth="1.0"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="150" /> </Outputs> <Catalysts> <Catalyst id="142" points="856 134" /> </Catalysts> <Properties> <displayName>MCM2-7 mediated fork unwinding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="169461" points="941 102, 951 133, 938 176" position="951 133" lineWidth="1.0"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="150" /> </Outputs> <Catalysts> <Catalyst id="224" points="983 132" /> </Catalysts> <Properties> <displayName>MCM8 mediated fork unwinding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="176956" points="992 416, 1029 416, 1055 415" position="1029 416" lineWidth="1.0"> <Inputs> <Input id="242" points="933 420" /> <Input id="172" points="935 394" /> <Input id="170" points="939 449" /> <Input id="171" points="928 359" /> </Inputs> <Outputs> <Output id="174" /> </Outputs> <Properties> <displayName>Formation of GINS complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="175" reactomeId="176942" points="1196 413, 1236 412, 1271 413" position="1236 412" lineWidth="1.0"> <Inputs> <Input id="174" points="1154 413" /> <Input id="142" points="797 122, 800 60, 1181 58" /> <Input id="149" points="997 87, 1165 87" /> <Input id="176" points="1109 451" /> </Inputs> <Outputs> <Output id="177" /> </Outputs> <Properties> <displayName>Multiple proteins are localized at replication fork</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="69053" points="654 556, 684 556, 743 557" position="684 556" lineWidth="1.0"> <Inputs> <Input id="179" points="692 645" /> <Input id="95" points="549 416" /> </Inputs> <Outputs> <Output id="180" /> </Outputs> <Properties> <displayName>RFC binding displaces Pol Alpha</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="69063" points="920 625, 950 625, 991 625" position="950 625" lineWidth="1.0"> <Inputs> <Input id="182" points="875 625" /> <Input id="180" points="861 591" /> <Input id="183" points="881 662" /> </Inputs> <Outputs> <Output id="184" points="1010 610" /> <Output id="185" points="1045 679" /> </Outputs> <Properties> <displayName>Loading of PCNA - Sliding Clamp Formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="69068" points="1031 728, 815 729, 755 728" position="815 729" lineWidth="1.0"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="179" points="709 677" /> <Output id="187" points="712 766" /> </Outputs> <Properties> <displayName>RFC dissociates after sliding clamp formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="188" reactomeId="69074" points="836 799, 836 821, 836 851" position="836 821" lineWidth="1.0"> <Inputs> <Input id="189" points="891 790" /> <Input id="187" points="746 795" /> </Inputs> <Outputs> <Output id="190" /> </Outputs> <Properties> <displayName>Formation of Processive Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="199" reactomeId="69116" points="905 864, 951 864, 999 864" position="951 864" lineWidth="1.0"> <Inputs> <Input id="190" /> </Inputs> <Outputs> <Output id="200" /> </Outputs> <Catalysts> <Catalyst id="189" points="951 803" /> </Catalysts> <Properties> <displayName>Formation of Okazaki fragments</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="201" reactomeId="69127" points="1130 864, 1301 864, 1367 865" position="1301 864" lineWidth="1.0"> <Inputs> <Input id="200" /> </Inputs> <Outputs> <Output id="202" /> </Outputs> <Properties> <displayName>Formation of the Flap Intermediate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="203" reactomeId="69140" points="1473 800, 1518 800, 1620 735" position="1518 800" lineWidth="1.0"> <Inputs> <Input id="202" points="1447 839" /> <Input id="204" points="1451 767" /> </Inputs> <Outputs> <Output id="205" /> </Outputs> <Properties> <displayName>RPA binds to the Flap</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="69142" points="1575 636, 1575 606, 1574 570" position="1575 606" lineWidth="1.0"> <Inputs> <Input id="207" points="1538 680" /> <Input id="205" points="1621 665" /> </Inputs> <Outputs> <Output id="208" /> </Outputs> <Properties> <displayName>Recruitment of Dna2 endonuclease</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="209" reactomeId="69144" points="1572 500, 1571 476, 1571 454" position="1571 476" lineWidth="1.0"> <Inputs> <Input id="208" /> </Inputs> <Outputs> <Output id="210" points="1531 398" /> <Output id="207" points="1528 680, 1490 516" /> <Output id="211" points="1606 392" /> <Output id="212" points="1650 431" /> <Output id="204" points="1446 739, 1467 516" /> <Output id="213" points="1504 435" /> <Output id="214" points="1568 325" /> </Outputs> <Properties> <displayName>Removal of RNA primer and dissociation of RPA and Dna2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="215" reactomeId="69152" points="1567 265, 1567 233, 1568 198" position="1567 233" lineWidth="1.0"> <Inputs> <Input id="214" /> </Inputs> <Outputs> <Output id="216" /> </Outputs> <Catalysts> <Catalyst id="217" points="1526 233" /> </Catalysts> <Properties> <displayName>Removal of remaining Flap</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="218" reactomeId="69173" points="1415 108, 1442 109, 1639 108" position="1442 109" lineWidth="1.0"> <Inputs> <Input id="219" /> </Inputs> <Outputs> <Output id="220" /> </Outputs> <Catalysts> <Catalyst id="243" points="1441 79" /> </Catalysts> <Properties> <displayName>Joining of adjacent Okazaki fragments</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="68913" points="218 195, 260 194, 291 193" position="260 194" lineWidth="1.0"> <Inputs> <Input id="268" points="182 236" /> <Input id="245" points="185 181" /> </Inputs> <Outputs> <Output id="86" points="311 210" /> <Output id="250" points="322 156" /> </Outputs> <Catalysts> <Catalyst id="245" points="185 157, 259 159" /> </Catalysts> <Properties> <displayName>The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="251" reactomeId="68950" points="531 253, 532 321, 534 369" position="532 321" lineWidth="1.0"> <Inputs> <Input id="252" points="564 185" /> <Input id="253" points="509 185" /> <Input id="254" points="580 224" /> <Input id="86" points="409 247" /> <Input id="255" points="496 228" /> </Inputs> <Outputs> <Output id="95" /> </Outputs> <Catalysts> <Catalyst id="256" points="491 322" /> </Catalysts> <Properties> <displayName>The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="262" points="494 632, 544 772" position="519 702" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="257" /> </Inputs> <Outputs> <Output id="261" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="264" reactomeId="69299" points="177 413, 212 419, 283 417" position="212 419" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="265" points="143 395" /> <Input id="266" points="132 439" /> </Inputs> <Outputs> <Output id="267" /> </Outputs> <Properties> <displayName>CDT1 binds geminin</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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