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Details on Person UniProt:P17643 TYRP1
| Class:Id | ReferenceGeneProduct:66641 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-537 added on Fri February 6 2015 |
| _displayName | UniProt:P17643 TYRP1 |
| _timestamp | 2025-05-21 21:16:02 |
| chain | signal peptide:1-24 chain:25-537 |
| checksum | 1051CEEF52908CCA |
| comment | FUNCTION Plays a role in melanin biosynthesis (PubMed:16704458, PubMed:22556244, PubMed:23504663). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:16704458, PubMed:22556244). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).CATALYTIC ACTIVITY 2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 indole-5,6-quinone-2-carboxylate + 2 H2OCOFACTOR Contains bound zinc ions after heterologous expression in insect cells, giving rise to a protein that lacks DHICA oxidase activity.ACTIVITY REGULATION The activity depends critically on the nature of the bound metal ion. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the presence of bound Cu(2+) ions, but lacks activity in the presence of bound Zn(2+) ions.PATHWAY Pigment biosynthesis; melanin biosynthesis.SUBUNIT Monomer (PubMed:28661582). Interacts with ATP7A (By similarity) (PubMed:28661582). Interacts with SLC45A2 (By similarity).INTERACTION Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.TISSUE SPECIFICITY Pigment cells.PTM Glycosylated.POLYMORPHISM Genetic variants in TYRP1 define the skin/hair/eye pigmentation variation locus 11 (SHEP11) [MIM:612271] and are responsible for variability in hair color linked to chromosome 9p23 in Melanesians. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tyrosinase family.CAUTION The precise function of this protein in melanin biosynthesis is still under debate. DHICA oxidase activity is controversial (PubMed:28661582, PubMed:9758418). Lacks DHICA oxidase activity (PubMed:9758418). Has DHICA oxidase activity in the presence of Cu(2+), but lacks DHICA oxidase activity with Zn(2+) (PubMed:28661582).ONLINE INFORMATION TYRP1 mutations |
| description | recommendedName: 5,6-dihydroxyindole-2-carboxylic acid oxidase shortName: DHICA oxidase ecNumber evidence="6"1.14.18.- alternativeName: Catalase B alternativeName: fullName evidence="8"Glycoprotein 75 alternativeName: fullName evidence="11"Melanoma antigen gp75 alternativeName: fullName evidence="12"Tyrosinase-related protein 1 shortName evidence="10"TRP shortName: TRP-1 shortName: TRP1 |
| geneName | TYRP1 CAS2 TYRP TYRRP |
| identifier | P17643 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Albinism Copper Direct protein sequencing Disease variant Disulfide bond Glycoprotein Melanin biosynthesis Membrane Metal-binding Monooxygenase Oxidoreductase Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | TYRP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994587] ENSEMBL:ENSG00000107165 TYRP1 [Homo sapiens] |
| secondaryIdentifier | TYRP1_HUMAN P78468 P78469 Q13721 Q15679 |
| sequenceLength | 537 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8878574] TYRP1 [melanosome membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P17643 TYRP1 (66641)
