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Details on Person UniProt:P29597 TYK2
| Class:Id | ReferenceGeneProduct:66635 |
|---|---|
| _chainChangeLog | chain:1-1187 added on Fri February 6 2015 |
| _displayName | UniProt:P29597 TYK2 |
| _timestamp | 2025-02-21 20:05:06 |
| chain | chain:1-1187 |
| checksum | F76C25D6A919EDBC |
| comment | FUNCTION Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)ACTIVITY REGULATION The protein kinase 1 domain (also termed pseudokinase domain) mediates autoinhibition of the TYK2 kinase domain.SUBUNIT Interacts (via FERM domain) with JAKMIP1 (PubMed:15277531, PubMed:20478313). Interacts with PIK3R1; this interaction is important for cell migration (PubMed:10995743). Interacts with MPL/TPOR (PubMed:15899890).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus protein LMP1; this interaction inhibits TYK2-mediated interferon signaling.SUBUNIT (Microbial infection) Interacts with papillomavirus-18 protein E6; this interaction impairs JAK-STAT activation by interferon-alpha.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus (EBV) tegument protein BGLF2; this interaction participates in the inhibition of type I IFN signaling by the virus.INTERACTION Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.PTM Phosphorylated (PubMed:7638186). Phosphorylation by JAK1 at Tyr-1054 and Tyr-1055 induces kinase activation (PubMed:8232552, PubMed:8702790).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.ONLINE INFORMATION tyrosine kinase 2 |
| description | recommendedName: Non-receptor tyrosine-protein kinase TYK2 ecNumber evidence="7 21"2.7.10.2 |
| geneName | TYK2 |
| identifier | P29597 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Kinase Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat SH2 domain Transferase Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TYK2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999835] ENSEMBL:ENSG00000105397 TYK2 [Homo sapiens] |
| secondaryIdentifier | TYK2_HUMAN Q6QB10 Q96CH0 |
| sequenceLength | 1187 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:877348] TYK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:909682] p-Y1054,Y1055-TYK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1112598] p-Y1054-TYK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6784366] p-Y-TYK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8950424] p-TYK2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:909677] O4'-phospho-L-tyrosine at 1054 [ModifiedResidue:909679] O4'-phospho-L-tyrosine at 1055 [ModifiedResidue:6784321] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:8950281] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P29597 TYK2 (66635)
