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Details on Person UniProt:P62328 TMSB4X
| Class:Id | ReferenceGeneProduct:66621 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-44 added on Fri February 6 2015;peptide:2-5 added on Fri February 6 2015;initiator methionine:1 for 66621 removed on Fri Nov 03 2023;initiator methionine: for 66621 added on Fri Nov 03 2023;initiator methionine: for 66621 removed on Fri Aug 15 2025;initiator methionine:1 for 66621 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62328 TMSB4X |
| _timestamp | 2025-08-15 21:42:29 |
| chain | initiator methionine:1 chain:2-44 peptide:2-5 |
| checksum | 440C6158482DAAD0 |
| comment | FUNCTION Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398).FUNCTION Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).SUBUNIT Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (PubMed:23009842). Interacts with SERPINB1 (By similarity).INTERACTION Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.INDUCTION By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda.PTM AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.SIMILARITY Belongs to the thymosin beta family. |
| description | recommendedName: fullName evidence="13"Thymosin beta-4 shortName: T beta-4 alternativeName: fullName evidence="12"Fx component recommendedName: fullName evidence="15"Hemoregulatory peptide AcSDKP alternativeName: fullName evidence="14"Ac-Ser-Asp-Lys-Pro alternativeName: N-acetyl-SDKP shortName evidence="14"AcSDKP alternativeName: fullName evidence="14"Seraspenide /component |
| geneName | TMSB4X TB4X THYB4 TMSB4 |
| identifier | P62328 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TMSB4X |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957833] ENSEMBL:ENSG00000205542 TMSB4X [Homo sapiens] |
| secondaryIdentifier | TYB4_HUMAN P01253 P01254 Q546P5 Q63576 Q9UE55 |
| sequenceLength | 44 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:216899] TMSB4X [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:349753] TMSB4X [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:349758] TMSB4X [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62328 TMSB4X (66621)
