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Details on Person UniProt:Q9UL62 TRPC5
| Class:Id | ReferenceGeneProduct:66463 |
|---|---|
| _chainChangeLog | chain:1-973 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UL62 TRPC5 |
| _timestamp | 2026-02-20 21:45:36 |
| chain | chain:1-973 |
| checksum | FBC8CBF17BE42166 |
| comment | FUNCTION Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)ACTIVITY REGULATION Activated by G-protein coupled receptors via direct interaction with GTP-bound GNAI3, which increases the channel sensitivity to phosphatidylinositol bisphosphate (PubMed:37137991). May be activated by intracellular calcium store depletion. Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.SUBUNIT Homotetramer (PubMed:12032305, PubMed:37137991). Heterotetramer with TRPC1 and/or TRPC4 (PubMed:12032305). Each subunit in the homomeric ion channel (via ANK repeats) interacts with one copy of GTP-bound GNAI3; the interaction is direct and activates the ion channel (PubMed:37137991). Interacts with TRPC4AP (By similarity). Interacts with NHERF1 (By similarity). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865). Interacts (via C-terminus) with CABP1 (PubMed:15895247). Interacts with SESTD1 (via the spectrin 1 repeat) (PubMed:20164195). Interacts with PLSCR1 (PubMed:32110987). Interacts with PKD2L2 (PubMed:16883570).INTERACTION Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.DISEASE Loss-of-function variants in TRPC5 may be involved in a mental disorder characterized by maladaptive behavior, anxiety, autism, postpartum depression, extreme food-seeking and hoarding behavior, hyperphagia and obesity.SIMILARITY Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. |
| description | recommendedName: Short transient receptor potential channel 5 shortName: TrpC5 alternativeName: Transient receptor protein 5 shortName: TRP-5 shortName: hTRP-5 shortName: hTRP5 |
| geneName | TRPC5 TRP5 |
| identifier | Q9UL62 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ANK repeat Calcium Calcium channel Calcium transport Cell membrane Disease variant Disulfide bond Glycoprotein Ion channel Ion transport Membrane Metal-binding Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix Transport Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TRPC5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992798] ENSEMBL:ENSG00000072315 TRPC5 [Homo sapiens] |
| secondaryIdentifier | TRPC5_HUMAN B2RP53 O75233 Q5JXY8 Q9Y514 |
| sequenceLength | 973 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:612170] TRPC5 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UL62 TRPC5 (66463)
