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Details on Person UniProt:Q15652 JMJD1C
| Class:Id | ReferenceGeneProduct:66417 |
|---|---|
| _chainChangeLog | chain:1-2540 added on Fri February 6 2015 |
| _displayName | UniProt:Q15652 JMJD1C |
| _timestamp | 2026-02-20 21:50:12 |
| chain | chain:1-2540 |
| checksum | 8B1727414D6B677F |
| comment | FUNCTION Demethylates lysine in proteins, such as STAT3 or MDC1 (By similarity) (PubMed:24240613). Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair (PubMed:24240613). Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation (By similarity). It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do (PubMed:23593242, PubMed:24240613, PubMed:32034158). Nevertheless, JMJD1C may act as a context-specific histone demethylase. Implicated in lipogenic gene transcription in the liver, where USF1 recruits JMJD1C to lipogenic promoters in response to insulin or feeding stimuli, thereby potentially promoting H3K9me2 demethylation and enhancing chromatin accessibility (PubMed:32034158). Post-translational modifications may regulate JMJD1C's enzymatic activity, contributing to its context-specific functions (PubMed:32034158). Alternatively, JMJD1C may influence chromatin regulation indirectly, acting as a scaffold or co-regulator that recruits or stabilizes other active demethylase complexes modifying histone marks (PubMed:24240613). Plays an indispensable role in spermatogenesis (By similarity).FUNCTION Coactivator of androgen receptor.COFACTOR Binds 1 Fe(2+) ion per subunit.ACTIVITY REGULATION Demethylase activity is regulated post-translationally via phosphorylation.SUBUNIT Interacts with RNF8; promotes interaction between RNF8 and MDC1 through demethylation of MDC1.INTERACTION Ubiquitinated. Protein abundance of JMJD1C is regulated by the ubiquitin proteasome pathway.PTM Phosphorylated. Phosphorylation at Thr-505 by mTORC1 complex in response to insulin/feeding.SIMILARITY Belongs to the JHDM2 histone demethylase family.CAUTION It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD/KDM3 proteins do. Independent studies show conflicting conclusions that either succeeded or failed to substantiate the existence of histone demethylase activity of JMJD1C (PubMed:23593242, PubMed:24240613, PubMed:32034158). This conflicting data suggests JMJD1C's role may be context-dependent. It may be possible that JMJD1C contributes to H3K9 demethylation in the very restricted regions of the genome. |
| description | recommendedName: fullName evidence="17"Jumonji domain-containing protein 1C ecNumber evidence="8 9"1.14.11.- alternativeName: fullName evidence="11 14"Thyroid receptor-interacting protein 8 shortName: TR-interacting protein 8 shortName: TRIP-8 |
| geneName | JMJD1C JHDM2C KDM3C KIAA1380 TRIP8 |
| identifier | Q15652 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Dioxygenase Iron Isopeptide bond Metal-binding Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | JMJD1C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958045] ENSEMBL:ENSG00000171988 JMJD1C [Homo sapiens] |
| secondaryIdentifier | JHD2C_HUMAN A0T124 Q5SQZ8 Q5SQZ9 Q5SR00 Q7Z3E7 Q8N3U0 Q96KB9 Q9P2G7 |
| sequenceLength | 2540 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:233246] UniProt:Q15652-2 JMJD1C [Homo sapiens] [ReferenceIsoform:405877] UniProt:Q15652-1 JMJD1C [Homo sapiens] [ReferenceIsoform:8972893] UniProt:Q15652-3 JMJD1C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:997258] JMJD1C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8957951] JMJD1C [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15652 JMJD1C (66417)
