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Details on Person UniProt:Q12931 TRAP1
| Class:Id | ReferenceGeneProduct:66379 |
|---|---|
| _chainChangeLog | transit peptide:1-59 added on Sat February 7 2015;chain:60-704 added on Sat February 7 2015 |
| _displayName | UniProt:Q12931 TRAP1 |
| _timestamp | 2024-11-03 20:17:11 |
| chain | transit peptide:1-59 chain:60-704 |
| checksum | 4B16DE3D2B9E0285 |
| comment | FUNCTION Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.SUBUNIT Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.INTERACTION Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.SIMILARITY Belongs to the heat shock protein 90 family. |
| description | recommendedName: Heat shock protein 75 kDa, mitochondrial shortName: HSP 75 alternativeName: fullName evidence="11"Heat shock protein family C member 5 alternativeName: TNFR-associated protein 1 alternativeName: Tumor necrosis factor type 1 receptor-associated protein shortName: TRAP-1 |
| geneName | TRAP1 HSP75 HSPC5 |
| identifier | Q12931 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Chaperone Membrane Mitochondrion Mitochondrion inner membrane Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TRAP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005037] ENSEMBL:ENSG00000126602 TRAP1 [Homo sapiens] |
| secondaryIdentifier | TRAP1_HUMAN B4DR68 D3DUC8 F5H897 O43642 O75235 Q9UHL5 |
| sequenceLength | 704 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974099] UniProt:Q12931-1 TRAP1 [Homo sapiens] [ReferenceIsoform:8974100] UniProt:Q12931-2 TRAP1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8874494] TRAP1 [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q12931 TRAP1 (66379)
