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Details on Person UniProt:Q15628 TRADD
| Class:Id | ReferenceGeneProduct:66377 |
|---|---|
| _chainChangeLog | chain:1-312 added on Sat February 7 2015 |
| _displayName | UniProt:Q15628 TRADD |
| _timestamp | 2026-02-20 23:12:28 |
| chain | chain:1-312 |
| checksum | 5645D7E63E5FF05A |
| comment | FUNCTION Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:23955153, PubMed:7758105, PubMed:8612133). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).SUBUNIT Stimulation of TNF receptor TNFRSF1A leads to the formation of two distinct signaling complexes (PubMed:14585990, PubMed:21307340, PubMed:7758105, PubMed:8612133). Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:14585990, PubMed:21307340, PubMed:7758105, PubMed:8612133). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (PubMed:21307340). Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1 (PubMed:10892748, PubMed:7758105, PubMed:8612133). Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation (PubMed:14585990). UXT1 associates with complex I; the interaction prevents the formation of complex II (PubMed:21307340). Within complex I Interacts with scaffold protein DAB2IP (PubMed:15310755). Interacts with autophagy receptor SQSTM1 (PubMed:10356400). Interacts with E3 ligase TRIP12 (By similarity). Interacts with kinase HIPK2 (PubMed:11032752). Interacts with keratin KRT14 (PubMed:11684708). Interacts with keratin KRT18 (PubMed:11684708). Interacts with keratins KRT16 and KRT17 (By similarity). Interacts with FADD (By similarity). Interacts with TOMM70 (PubMed:20628368). Interacts with TMC8; the interaction impairs the formation of complex I and facilites complex II formation (PubMed:23429285).INTERACTION Shuttles between the cytoplasm and the nucleus.ALTERNATIVE PRODUCTS Found in all examined tissues.DOMAIN Requires the intact death domain to associate with TNFRSF1A/TNFR1.PTM (Microbial infection) Glycosylated at Arg-235 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium proteins Ssek1 and Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="24"Tumor necrosis factor receptor type 1-associated DEATH domain protein shortName evidence="23"TNFR1-associated DEATH domain protein alternativeName: fullName evidence="23"TNFRSF1A-associated via death domain |
| geneName | TRADD |
| identifier | Q15628 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytoplasm Cytoskeleton Glycoprotein Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TRADD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002708] ENSEMBL:ENSG00000102871 TRADD [Homo sapiens] |
| secondaryIdentifier | TRADD_HUMAN B2RDS3 B3KQZ9 Q52NZ1 |
| sequenceLength | 312 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971708] UniProt:Q15628-1 TRADD [Homo sapiens] [ReferenceIsoform:8971709] UniProt:Q15628-2 TRADD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15628 TRADD (66377)
