Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P67936 TPM4

Class:Id	ReferenceGeneProduct:66303
_chainChangeLog	initiator methionine:1 added on Sat February 7 2015;chain:2-248 added on Sat February 7 2015;initiator methionine:1 for 66303 removed on Fri Nov 03 2023;initiator methionine: for 66303 added on Fri Nov 03 2023;initiator methionine: for 66303 removed on Fri Aug 15 2025;initiator methionine:1 for 66303 added on Fri Aug 15 2025
_displayName	UniProt:P67936 TPM4
_timestamp	2025-08-15 21:34:48
chain	initiator methionine:1 chain:2-248
checksum	5D5CDF6BF76552A8
comment	FUNCTION Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis.SUBUNIT Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.INTERACTION Associates with F-actin stress fibers.ALTERNATIVE PRODUCTS Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).DOMAIN The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tropomyosin family.
description	recommendedName: Tropomyosin alpha-4 chain alternativeName: TM30p1 alternativeName: Tropomyosin-4
geneName	TPM4
identifier	P67936
isSequenceChanged	FALSE
keyword	Acetylation Actin-binding Alternative splicing Calcium Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Metal-binding Muscle protein Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	TPM4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958623] ENSEMBL:ENSG00000167460 TPM4 [Homo sapiens]
secondaryIdentifier	TPM4_HUMAN P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4
sequenceLength	248
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:155096] UniProt:P67936-2 TPM4 [Homo sapiens] [ReferenceIsoform:404700] UniProt:P67936-1 TPM4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:390548] TPM4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8958274] TPM4 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9710841] TPM4(2-222)insV-p-7Y-ALK(1059-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9710851] TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol] [Homo sapiens]
(referenceSequence)	[FragmentReplacedModification:9710849] Replacement of residues 222 to 222 by EV
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P67936 TPM4 (66303)