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Details on Person UniProt:P25445 FAS
| Class:Id | ReferenceGeneProduct:66249 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-335 added on Fri February 6 2015 |
| _displayName | UniProt:P25445 FAS |
| _timestamp | 2024-11-03 20:12:28 |
| chain | signal peptide:1-25 chain:26-335 |
| checksum | 0139942535111410 |
| comment | FUNCTION Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).SUBUNIT Component of the death-induced signaling complex (DISC) composed of cell surface receptor FAS/CD95, adapter protein FADD and the CASP8 protease; recruitment of CASP8 to the complex is required for processing of CASP8 into the p18 and p10 subunits (PubMed:21109225, PubMed:9184224, PubMed:9322534). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Binds DAXX. Interacts with HIPK3 (By similarity). Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2 (PubMed:10535980, PubMed:7538908). Interacts with BABAM2 and FEM1B (PubMed:10542291, PubMed:15465831). Interacts with CALM (PubMed:24914971). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (PubMed:18846110).INTERACTION Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.DOMAIN Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.PTM (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.PTM Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068).PTM N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS Dominant negative isoform, resistant to Fas-mediated apoptosis.ONLINE INFORMATION Mutations in TNFRSF6 causing ALPS type Ia |
| description | recommendedName: Tumor necrosis factor receptor superfamily member 6 alternativeName: Apo-1 antigen alternativeName: Apoptosis-mediating surface antigen FAS alternativeName: FASLG receptor cdAntigenNameCD95/cdAntigenName |
| geneName | FAS APT1 FAS1 TNFRSF6 |
| identifier | P25445 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Calmodulin-binding Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FAS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6799809] ENSEMBL:ENSG00000026103 FAS [Homo sapiens] |
| secondaryIdentifier | TNR6_HUMAN A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3 Q6SSE9 |
| sequenceLength | 335 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155033] UniProt:P25445-2 FAS [Homo sapiens] [ReferenceIsoform:155034] UniProt:P25445-3 FAS [Homo sapiens] [ReferenceIsoform:155035] UniProt:P25445-4 FAS [Homo sapiens] [ReferenceIsoform:155036] UniProt:P25445-5 FAS [Homo sapiens] [ReferenceIsoform:155037] UniProt:P25445-6 FAS [Homo sapiens] [ReferenceIsoform:403443] UniProt:P25445-1 FAS [Homo sapiens] [ReferenceIsoform:8972627] UniProt:P25445-7 FAS [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:66248] FAS [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P25445 FAS (66249)
