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Details on Person UniProt:P25942-1 CD40
| Class:Id | ReferenceIsoform:66247 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-277 added on Sat February 7 2015 |
| _displayName | UniProt:P25942-1 CD40 |
| _timestamp | 2024-11-03 20:03:39 |
| chain | signal peptide:1-20 chain:21-277 |
| checksum | BC8776EC2C4A5680 |
| comment | FUNCTION Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).SUBUNIT Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY B-cells and in primary carcinomas.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION CD40 mutation dbONLINE INFORMATION CD40 entry |
| description | recommendedName: Tumor necrosis factor receptor superfamily member 5 alternativeName: B-cell surface antigen CD40 alternativeName: Bp50 alternativeName: CD40L receptor alternativeName: CDw40 cdAntigenNameCD40/cdAntigenName |
| geneName | CD40 TNFRSF5 |
| identifier | P25942 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunity Membrane Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CD40 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005031] ENSEMBL:ENSG00000101017 CD40 [Homo sapiens] |
| secondaryIdentifier | TNR5_HUMAN E1P5S9 Q53GN5 Q5JY15 Q5U007 Q7M4Q8 Q86YK5 Q9BYU0 |
| sequenceLength | 277 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P25942-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:198117] CD40-1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9696677] CD40-1 [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:9946738] CD40-1 (GC B cell) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P25942-1 CD40 (66247)
