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Details on Person UniProt:Q9H2K2 TNKS2
| Class:Id | ReferenceGeneProduct:66233 |
|---|---|
| _chainChangeLog | chain:1-1166 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H2K2 TNKS2 |
| _timestamp | 2024-11-03 19:43:56 |
| chain | chain:1-1166 |
| checksum | 4C8B3B8D97CEF704 |
| comment | FUNCTION Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245).CATALYTIC ACTIVITY NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).CATALYTIC ACTIVITY L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamideCATALYTIC ACTIVITY L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamideACTIVITY REGULATION Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2 (PubMed:19759537). Inhibited by talazoparib (PubMed:33361107).SUBUNIT Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles (PubMed:11802774). Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region (PubMed:11802774). Interacts with HIF1AN (PubMed:18936059, PubMed:21251231). Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation (PubMed:21799911). Interacts with NUMA1 (PubMed:12080061).INTERACTION Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.TISSUE SPECIFICITY Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.PTM Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation. Deubiquitinated by USP25; leading to stabilization (By similarity).PTM ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.PTM The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.SIMILARITY Belongs to the ARTD/PARP family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="17"Poly [ADP-ribose] polymerase tankyrase-2 ecNumber evidence="9 11"2.4.2.30 alternativeName: fullName evidence="16"ADP-ribosyltransferase diphtheria toxin-like 6 shortName evidence="16"ARTD6 alternativeName: fullName evidence="16"Poly [ADP-ribose] polymerase 5B alternativeName: fullName evidence="17"Protein poly-ADP-ribosyltransferase tankyrase-2 ecNumber evidence="9 14"2.4.2.- alternativeName: TNKS-2 alternativeName: TRF1-interacting ankyrin-related ADP-ribose polymerase 2 alternativeName: Tankyrase II alternativeName: Tankyrase-2 shortName: TANK2 alternativeName: Tankyrase-like protein alternativeName: Tankyrase-related protein |
| geneName | TNKS2 PARP5B TANK2 TNKL |
| identifier | Q9H2K2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ADP-ribosylation ANK repeat Chromosome Cytoplasm Glycosyltransferase Golgi apparatus Hydroxylation Membrane Metal-binding NAD Nucleotidyltransferase Nucleus Proteomics identification Reference proteome Repeat Telomere Transferase Ubl conjugation Wnt signaling pathway Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNKS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001508] ENSEMBL:ENSG00000107854 TNKS2 [Homo sapiens] |
| secondaryIdentifier | TNKS2_HUMAN B2RBD3 Q9H8F2 Q9HAS4 |
| sequenceLength | 1166 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:174880] TNKS2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3640824] TNKS2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H2K2 TNKS2 (66233)
