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Details on Person UniProt:O43557 TNFSF14
| Class:Id | ReferenceGeneProduct:66195 |
|---|---|
| _chainChangeLog | chain:1-240 added on Fri February 6 2015;chain:-240 added on Fri February 6 2015 |
| _displayName | UniProt:O43557 TNFSF14 |
| _timestamp | 2024-11-03 19:49:10 |
| chain | chain:1-240 chain:83-240 |
| checksum | 49D0B1870F390B39 |
| comment | FUNCTION Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).SUBUNIT Homotrimer. Interacts with TNFRSF14.INTERACTION Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.INDUCTION Up-regulated after T-cell activation.PTM N-glycosylated.PTM The soluble form of isoform 1 derives from the membrane form by proteolytic processing.SIMILARITY Belongs to the tumor necrosis factor family. |
| description | recommendedName: Tumor necrosis factor ligand superfamily member 14 alternativeName: Herpes virus entry mediator ligand shortName: HVEM-L shortName: Herpesvirus entry mediator ligand cdAntigenNameCD258/cdAntigenName component recommendedName: Tumor necrosis factor ligand superfamily member 14, membrane form /component component recommendedName: Tumor necrosis factor ligand superfamily member 14, soluble form /component |
| geneName | TNFSF14 HVEML LIGHT UNQ391/PRO726 |
| identifier | O43557 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytokine Cytoplasm Disulfide bond Glycoprotein Membrane Proteomics identification Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNFSF14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002699] ENSEMBL:ENSG00000125735 TNFSF14 [Homo sapiens] |
| secondaryIdentifier | TNF14_HUMAN A8K7M2 C9J5H4 O75476 Q6FHA1 Q8WVF8 Q96LD2 |
| sequenceLength | 240 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155010] UniProt:O43557-2 TNFSF14 [Homo sapiens] [ReferenceIsoform:401539] UniProt:O43557-1 TNFSF14 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5667149] TNFSF14 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43557 TNFSF14 (66195)
