Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O75888 TNFSF13
| Class:Id | ReferenceGeneProduct:66193 |
|---|---|
| _chainChangeLog | propeptide:1-104 added on Fri February 6 2015;chain:105-250 added on Fri February 6 2015 |
| _displayName | UniProt:O75888 TNFSF13 |
| _timestamp | 2024-11-03 19:49:10 |
| chain | propeptide:1-104 chain:105-250 |
| checksum | AE1A6B9457F6E298 |
| comment | FUNCTION Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.SUBUNIT Homotrimer.INTERACTION Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.INDUCTION Down-regulated by phorbol myristate acetate/ionomycin treatment.PTM The precursor is cleaved by furin.SIMILARITY Belongs to the tumor necrosis factor family. |
| description | recommendedName: Tumor necrosis factor ligand superfamily member 13 alternativeName: A proliferation-inducing ligand shortName: APRIL alternativeName: TNF- and APOL-related leukocyte expressed ligand 2 shortName: TALL-2 alternativeName: TNF-related death ligand 1 shortName: TRDL-1 cdAntigenNameCD256/cdAntigenName |
| geneName | TNFSF13 APRIL TALL2 ZTNF2 UNQ383/PRO715 |
| identifier | O75888 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cleavage on pair of basic residues Cytokine Disulfide bond Glycoprotein Immunity Proteomics identification Reference proteome Secreted |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNFSF13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998054] ENSEMBL:ENSG00000161955 TNFSF13 [Homo sapiens] |
| secondaryIdentifier | TNF13_HUMAN A8MYD5 B4DVT2 Q541E1 Q5U0G8 Q96HV6 Q9P1M8 Q9P1M9 |
| sequenceLength | 250 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:155008] UniProt:O75888-2 TNFSF13 [Homo sapiens] [ReferenceIsoform:155009] UniProt:O75888-3 TNFSF13 [Homo sapiens] [ReferenceIsoform:401901] UniProt:O75888-1 TNFSF13 [Homo sapiens] [ReferenceIsoform:8966328] UniProt:O75888-4 TNFSF13 [Homo sapiens] [ReferenceIsoform:8966329] UniProt:O75888-5 TNFSF13 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:450603] p-T243-TNFSF13 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:450619] p-T243-TNFSF13 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5676560] sAPRIL [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:450460] O-phospho-L-threonine at 243 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75888 TNFSF13 (66193)
