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Details on Person UniProt:O43508 TNFSF12
| Class:Id | ReferenceGeneProduct:66191 |
|---|---|
| _chainChangeLog | chain:1-249 added on Fri February 6 2015;chain:94-249 added on Fri February 6 2015 |
| _displayName | UniProt:O43508 TNFSF12 |
| _timestamp | 2024-11-03 20:03:39 |
| chain | chain:1-249 chain:94-249 |
| checksum | E660843361C28EBA |
| comment | FUNCTION Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.SUBUNIT Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.INTERACTION Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.PTM The soluble form derives from the membrane form by proteolytic processing.MISCELLANEOUS Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines.SIMILARITY Belongs to the tumor necrosis factor family. |
| description | recommendedName: Tumor necrosis factor ligand superfamily member 12 alternativeName: APO3 ligand alternativeName: TNF-related weak inducer of apoptosis shortName: TWEAK component recommendedName: Tumor necrosis factor ligand superfamily member 12, membrane form /component component recommendedName: Tumor necrosis factor ligand superfamily member 12, secreted form /component |
| geneName | TNFSF12 APO3L DR3LG UNQ181/PRO207 |
| identifier | O43508 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Angiogenesis Apoptosis Cell membrane Cleavage on pair of basic residues Cytokine Developmental protein Differentiation Disulfide bond Glycoprotein Membrane Proteomics identification Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNFSF12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999222] ENSEMBL:ENSG00000239697 TNFSF12 [Homo sapiens] |
| secondaryIdentifier | TNF12_HUMAN Q8IZK7 Q8WUZ7 |
| sequenceLength | 249 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973102] UniProt:O43508-1 TNFSF12 [Homo sapiens] [ReferenceIsoform:8973103] UniProt:O43508-2 TNFSF12 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5667154] TNFSF12 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5675974] sTNFSF12 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43508 TNFSF12 (66191)
