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Details on Person UniProt:Q04725 TLE2
| Class:Id | ReferenceGeneProduct:66085 |
|---|---|
| _chainChangeLog | chain:1-743 added on Sat February 7 2015 |
| _displayName | UniProt:Q04725 TLE2 |
| _timestamp | 2024-11-03 20:17:05 |
| chain | chain:1-743 |
| checksum | 5E3DBFAB67278219 |
| comment | FUNCTION Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).SUBUNIT Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.INTERACTION In all tissues examined, mostly in heart, brain, and muscle.DOMAIN WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.PTM Ubiquitinated by XIAP/BIRC4.SIMILARITY Belongs to the WD repeat Groucho/TLE family. |
| description | recommendedName: Transducin-like enhancer protein 2 alternativeName: Enhancer of split groucho-like protein 2 shortName: ESG2 |
| geneName | TLE2 |
| identifier | Q04725 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation WD repeat Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TLE2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995184] ENSEMBL:ENSG00000065717 TLE2 [Homo sapiens] |
| secondaryIdentifier | TLE2_HUMAN B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0 |
| sequenceLength | 743 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965883] UniProt:Q04725-1 TLE2 [Homo sapiens] [ReferenceIsoform:8965884] UniProt:Q04725-2 TLE2 [Homo sapiens] [ReferenceIsoform:8965885] UniProt:Q04725-3 TLE2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:212354] TLE2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3322370] Ub-TLE2 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3322372] ubiquitinylated lysine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q04725 TLE2 (66085)
