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Details on Person UniProt:Q04724 TLE1
| Class:Id | ReferenceGeneProduct:66083 |
|---|---|
| _chainChangeLog | chain:1-770 added on Fri February 6 2015 |
| _displayName | UniProt:Q04724 TLE1 |
| _timestamp | 2024-11-03 20:17:05 |
| chain | chain:1-770 |
| checksum | 695FD1A37410EFE5 |
| comment | FUNCTION Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.SUBUNIT Homooligomer and heterooligomer with other family members. Binds RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Binds TCF7, LEF1, TCF7L1 and TCF7L2 (By similarity). Interacts with SIX3. Interacts with EFNB1. Interacts with TLE4 (By similarity). Interacts with FOXG1/BF-1; the interaction is inhibited by TLE6/GRG6 (By similarity).INTERACTION Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.TISSUE SPECIFICITY In all tissues examined, mostly in brain, liver and muscle.DOMAIN WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.PTM Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.PTM Ubiquitinated by XIAP/BIRC4.SIMILARITY Belongs to the WD repeat Groucho/TLE family. |
| description | recommendedName: Transducin-like enhancer protein 1 alternativeName: E(Sp1) homolog alternativeName: Enhancer of split groucho-like protein 1 shortName: ESG1 |
| geneName | TLE1 |
| identifier | Q04724 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation WD repeat Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TLE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005018] ENSEMBL:ENSG00000196781 TLE1 [Homo sapiens] |
| secondaryIdentifier | TLE1_HUMAN A8K495 Q5T3G4 Q969V9 |
| sequenceLength | 770 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:212327] TLE1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3322369] Ub-TLE1 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3322368] ubiquitinylated lysine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q04724 TLE1 (66083)
