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Details on Person UniProt:P20366 TAC1
| Class:Id | ReferenceGeneProduct:66075 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Sat February 7 2015;propeptide:20-56 added on Sat February 7 2015;peptide:58-68 added on Sat February 7 2015;peptide:72-107 added on Sat February 7 2015;peptide:72-73 added on Sat February 7 2015;peptide:89-107 added on Sat February 7 2015;peptide:98-107 added on Sat February 7 2015;peptide:111-126 added on Sat February 7 2015 |
| _displayName | UniProt:P20366 TAC1 |
| _timestamp | 2026-02-20 22:27:46 |
| chain | signal peptide:1-19 propeptide:20-56 peptide:58-68 peptide:72-107 peptide:72-73 peptide:89-107 peptide:98-107 peptide:111-126 |
| checksum | 51412C1692368DE4 |
| comment | FUNCTION Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.FUNCTION Is a ligand for TACR1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding to TACR1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is also a TACR3 agonist with low receptor affinity (PubMed:37391393). Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:30686732). Acts as a ligand for MRGPRX2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732, PubMed:34789875). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (By similarity). The inflammatory response can then activate or sensitize nociceptors, promoting pain (By similarity).FUNCTION Is a ligand for TACR2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:35882833). Binding to TACR2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP).INTERACTION The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).SIMILARITY Belongs to the tachykinin family.ONLINE INFORMATION Neurokinin-1 entry |
| description | recommendedName: Protachykinin-1 alternativeName: PPT component recommendedName: fullName evidence="13"Substance P /component component recommendedName: Neurokinin A shortName: NKA alternativeName: Neuromedin L alternativeName: Substance K /component component recommendedName: Neuropeptide K shortName: NPK /component component recommendedName: Neuropeptide gamma /component component recommendedName: C-terminal-flanking peptide /component |
| geneName | TAC1 NKA NKNA TAC2 |
| identifier | P20366 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Neuropeptide Neurotransmitter Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TAC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990454] ENSEMBL:ENSG00000006128 TAC1 [Homo sapiens] |
| secondaryIdentifier | TKN1_HUMAN O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1 |
| sequenceLength | 129 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154932] UniProt:P20366-2 TAC1 [Homo sapiens] [ReferenceIsoform:154933] UniProt:P20366-3 TAC1 [Homo sapiens] [ReferenceIsoform:154934] UniProt:P20366-4 TAC1 [Homo sapiens] [ReferenceIsoform:403228] UniProt:P20366-1 TAC1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:380066] TAC1(58-68) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:380131] TAC1(98-107) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P20366 TAC1 (66075)
