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Details on Person UniProt:Q9BSI4 TINF2
| Class:Id | ReferenceGeneProduct:66061 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-451 added on Fri February 6 2015;initiator methionine:1 for 66061 removed on Fri Nov 03 2023;initiator methionine: for 66061 added on Fri Nov 03 2023;initiator methionine: for 66061 removed on Fri Aug 15 2025;initiator methionine:1 for 66061 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BSI4 TINF2 |
| _timestamp | 2025-08-15 21:19:30 |
| chain | initiator methionine:1 chain:2-451 |
| checksum | E5A7FD11CE523979 |
| comment | FUNCTION Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.SUBUNIT Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF1, TERF2 and ACD.INTERACTION Associated with telomeres.SUBCELLULAR LOCATION Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN The TBM domain mediates interaction with TERF1.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: TERF1-interacting nuclear factor 2 alternativeName: TRF1-interacting nuclear protein 2 |
| geneName | TINF2 TIN2 |
| identifier | Q9BSI4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosome Disease variant Dyskeratosis congenita Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Telomere Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TINF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999208] ENSEMBL:ENSG00000092330 TINF2 [Homo sapiens] |
| secondaryIdentifier | TINF2_HUMAN B3W5Q7 Q9H904 Q9UHC2 |
| sequenceLength | 451 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154918] UniProt:Q9BSI4-2 TINF2 [Homo sapiens] [ReferenceIsoform:154919] UniProt:Q9BSI4-3 TINF2 [Homo sapiens] [ReferenceIsoform:413381] UniProt:Q9BSI4-1 TINF2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174883] TINF2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9007958] SUMO1-K-TINF2 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9007957] sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9BSI4 TINF2 (66061)
